昼夜节律与激素稳态：病理生理学意义
Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications.
作者信息
Gnocchi Davide, Bruscalupi Giovannella
机构信息
Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm 14186, Sweden.
Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome 00185, Italy.
出版信息
Biology (Basel). 2017 Feb 4;6(1):10. doi: 10.3390/biology6010010.
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation of our physiology, including hormonal and metabolic homeostasis. Here we will review the structure, organisation and molecular machinery that make our circadian clock work, and its relevance for the proper functioning of physiological processes. We will also describe the interconnections between circadian rhythms and endocrine homeostasis, as well as the underlying consequences that circadian dysregulations might have in the development of several pathologic affections. Finally, we will discuss how a better knowledge of such relationships might prove helpful in designing new therapeutic approaches for endocrine and metabolic diseases.
近年来，人们对控制生物钟和昼夜节律的分子机制有了更深入的理解。事实上，许多研究有助于揭示分子时钟对我们生理调节的重要性，包括激素和代谢稳态。在这里，我们将回顾使我们的生物钟发挥作用的结构、组织和分子机制，以及它对生理过程正常运作的相关性。我们还将描述昼夜节律与内分泌稳态之间的相互联系，以及昼夜节律失调在几种病理疾病发展中可能产生的潜在后果。最后，我们将讨论更好地了解这些关系如何有助于设计针对内分泌和代谢疾病的新治疗方法。
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