Fekrazad Reza, Nikkerdar Alireza, Joharchi Khojasteh, Kalhori Katayoun Am, Mashhadi Abbas Fatemeh, Salimi Vahid Fariborz
a AJA University of Medical Sciences , Tehran , Iran.
b Private Practice , London , UK.
J Cosmet Laser Ther. 2017 Aug;19(4):232-236. doi: 10.1080/14764172.2017.1288255. Epub 2017 Feb 6.
One of the most important innovative methods for tissue repair promotion is therapeutic lasers with photobiomodulution effects. The aim of this study was to investigate the effect of four different wavelengths of therapeutic laser (405, 532, 660 and 810 nm) on healing of third-degree burns from both clinical and pathological standpoints in rats.
60 male Wistar rats were used. Animals were anesthetized and dorsal hairs were shaved and third-degree skin burns were created by use of a 95°C copper stamp. Lesions were irradiated with 1.5 J/cm energy densities and 200 mW/cm power densities.
Statistical analyses of the "wound contraction" changes between five groups during the study showed more reduction in wound size in all laser groups in comparison with the control group; but these differences were not statistically significant except between red and blue lasers on the last day of experiment.
Results of our study showed that using therapeutic lasers with green, blue, red, and infrared wavelengths may accelerate healing process. This trend is more obvious in red and infrared groups especially after acute phase, however, this effect was neither statistically nor clinically significant.
促进组织修复的最重要创新方法之一是具有光生物调节作用的治疗性激光。本研究的目的是从临床和病理角度研究四种不同波长（405、532、660和810纳米）的治疗性激光对大鼠三度烧伤愈合的影响。
使用60只雄性Wistar大鼠。动物麻醉后剃去背部毛发，用95°C铜印造成三度皮肤烧伤。用1.5 J/cm的能量密度和200 mW/cm的功率密度对损伤部位进行照射。
研究期间五组之间“伤口收缩”变化的统计分析表明，与对照组相比，所有激光组的伤口大小减少更多；但除实验最后一天红色激光和蓝色激光之间外，这些差异无统计学意义。
我们的研究结果表明，使用绿色、蓝色、红色和红外波长的治疗性激光可能会加速愈合过程。这种趋势在红色和红外组中更明显，尤其是在急性期之后，然而，这种效果在统计学和临床上均无显著意义。
