Benson Tony, Corry Colette, O'Neill Siobhan, Murphy Sam, Bunting Brendan
Arch Suicide Res. 2018 Jan-Mar;22(1):139-152. doi: 10.1080/13811118.2017.1289870. Epub 2017 Mar 1.
To understand medication use prior to suicide in relation to patterns, polypharmacy, and adherence. A total of 1,371 suicide cases were coded and latent class analysis used to identify combinations of medications prescribed prior to death. Two thirds had been prescribed medication with 30.7% prescribed 3 or more. Latent class analysis revealed three classes: Mixed medication use, primarily mental medication use, and baseline/low medication use. There are potentially high rates of medication non-adherence. Not only medication use but also non-adherence rates were high in this sample of individuals who died by suicide. Potential implications and areas for future research are discussed.
了解自杀前的用药情况与用药模式、联合用药及依从性之间的关系。对总共1371例自杀病例进行编码,并采用潜在类别分析来确定死亡前开具的药物组合。三分之二的患者曾开具过药物,30.7%的患者开具了3种或更多药物。潜在类别分析揭示了三类:混合用药、主要使用精神类药物、基线/低用药量。药物不依从率可能很高。在这个自杀死亡个体样本中,不仅用药率高,不依从率也高。讨论了潜在影响和未来研究的领域。