Maurer Stefanie, Giglhuber Katrin, Sollmann Nico, Kelm Anna, Ille Sebastian, Hauck Theresa, Tanigawa Noriko, Ringel Florian, Boeckh-Behrens Tobias, Meyer Bernhard, Krieg Sandro M
Department of Neurosurgery, Klinikum Rechts der Isar, Technische Universität München Munich, Germany.
Faculty of Linguistics, Philology, and Phonetics, University of Oxford Oxford, UK.
Front Hum Neurosci. 2017 Jan 23;11:4. doi: 10.3389/fnhum.2017.00004. eCollection 2017.
Besides motor and language function, tumor resections within the frontal and parietal lobe have also been reported to cause neuropsychological impairment like prosopagnosia. Since non-navigated transcranial magnetic stimulation (TMS) has previously been used to map neuropsychological cortical function, this study aims to evaluate the feasibility and spatial discrimination of repetitive navigated TMS (rTMS) mapping for detection of face processing impairment in healthy volunteers. The study was also designed to establish this examination for preoperative mapping in brain tumor patients. Twenty healthy and purely right-handed volunteers (11 female, 9 male) underwent rTMS mapping for cortical face processing function using 5 Hz/10 pulses. Both hemispheres were investigated randomly with an interval of 2 weeks between mapping sessions. Fifty-two predetermined cortical spots of the whole hemispheres were mapped after baseline measurement. The task consisted of 80 portraits of popular persons, which had to be named while rTMS was applied. In 80% of all subjects rTMS elicited naming errors in the right middle middle frontal gyrus (mMFG). Concerning anomia errors, the highest error rate (35%) was achieved in the bilateral triangular inferior frontal gyrus (trIFG). With regard to similarly or wrongly named persons, we observed 10% error rates mainly in the bilateral frontal lobes. It seems feasible to map the cortical face processing function and to generate face processing impairment via rTMS. The observed localizations are well in accordance with the contemporary literature, and the mapping did not interfere with rTMS-induced language impairment. The clinical usefulness of preoperative mapping has to be evaluated subsequently.
除了运动和语言功能外，据报道额叶和顶叶内的肿瘤切除也会导致像面孔失认症这样的神经心理障碍。由于非导航经颅磁刺激（TMS）此前已被用于绘制神经心理皮层功能图，本研究旨在评估重复导航TMS（rTMS）映射在检测健康志愿者面部处理障碍方面的可行性和空间辨别力。该研究还旨在为脑肿瘤患者术前映射建立这种检查方法。20名健康且纯右利手的志愿者（11名女性，9名男性）接受了使用5Hz/10脉冲的rTMS映射以检测皮层面部处理功能。两个半球均随机进行研究，映射 sessions之间间隔2周。在基线测量后，对整个半球的52个预定皮层点进行了映射。任务包括80张名人肖像，在施加rTMS时必须对其进行命名。在所有受试者的80%中，rTMS在右侧额中回（mMFG）引发了命名错误。关于命名障碍错误，双侧额下回三角部（trIFG）的错误率最高（35%）。关于相似或错误命名的人，我们主要在双侧额叶观察到10%的错误率。通过rTMS映射皮层面部处理功能并产生面部处理障碍似乎是可行的。观察到的定位与当代文献非常一致，并且映射并未干扰rTMS诱发的语言障碍。术前映射的临床实用性随后必须进行评估。
