Vuddamalay Yirajen, van Meerwijk Joost P M
School of Health Sciences, University of Technology , Port Louis , Mauritius.
Institut National de la Santé et de la Recherche Médicale (INSERM), U1043, Toulouse, France; Centre National de la Recherche Scientifique (CNRS), U5282, Toulouse, France; Université de Toulouse, Université Paul Sabatier, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse, France.
Front Immunol. 2017 Jan 23;8:31. doi: 10.3389/fimmu.2017.00031. eCollection 2017.
Since the rebirth of regulatory (formerly known as suppressor) T cells in the early 1990s, research in the field of immune-regulation by various T cell populations has quickly gained momentum. While T cells expressing the transcription factor Foxp3 are currently in the spotlight, several other T cell populations endowed with potent immunomodulatory capacities have been identified in both the CD8 and CD4 compartment. The fundamental difference between CD4 and CD8 T cells in terms of antigen recognition suggests non-redundant, and perhaps complementary, functions of regulatory CD4 and CD8 T cells in immunoregulation. This emphasizes the importance and necessity of continuous research on both subpopulations of regulatory T cells (Tregs) so as to decipher their complex physiological relevance and possible synergy. Two distinct CD8-expressing Treg populations can be distinguished based on expression of the co-stimulatory receptor CD28. Here, we review the literature on these (at least in part) thymus-derived CD28 and peripherally induced CD28CD8 Tregs.
自20世纪90年代初调节性（原称抑制性）T细胞被重新发现以来，关于各种T细胞群体在免疫调节领域的研究迅速兴起。虽然目前表达转录因子Foxp3的T细胞备受关注，但在CD8和CD4细胞亚群中均已鉴定出其他几种具有强大免疫调节能力的T细胞群体。CD4和CD8 T细胞在抗原识别方面的根本差异表明，调节性CD4和CD8 T细胞在免疫调节中具有非冗余且可能互补的功能。这凸显了持续研究调节性T细胞（Tregs）这两个亚群的重要性和必要性，以便解读它们复杂的生理相关性及可能的协同作用。基于共刺激受体CD28的表达情况，可以区分出两种不同的表达CD8的Treg群体。在此，我们综述有关这些（至少部分）源自胸腺的CD28⁺和外周诱导的CD28⁻CD8⁺ Tregs的文献。
