Wang Xing-Jie, Zhuo Jian, Luo Guang-Heng, Zhu Yi-Ping, Yu Dian-Jun, Zhao Rui-Zhe, Jiang Chen-Yi, Shi Yun-Feng, Li Hao, Chen Lei, Hao Kui-Yuan, Han Xia, Zhao Sheng, Bei Xiao-Yu, Jing Yi-Feng, Xia Shu-Jie
Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Prostate. 2017 May;77(7):708-717. doi: 10.1002/pros.23301. Epub 2017 Feb 7.
Complications after a thulium laser resection of the prostate (TmLRP) are related to re-epithelialization of the prostatic urethra. Since prostate growth and development are induced by androgen, the aim of this study was to determine the role and explore the mechanism of androgen in wound healing of the prostatic urethra.
Beagles that received TmLRPs were randomly distributed into a castration group, a testosterone undecanoate (TU) group, and a control group. The prostate wound was assessed once a week using a cystoscope. Histological analysis was then carried out to study the re-epithelialization of the prostatic urethra in each group. The inflammatory response in the wound tissue and urine was also investigated.
The healing of the prostatic urethra after a TmLRP was more rapid in the castration group and slower in the TU group than that in the control group. Castration accelerated re-epithelialization by promoting basal cell proliferation in the wound surface and beneath the wound and by accelerating the differentiation of basal cells into urothelial cells. Castration reduced the duration of the inflammatory phase and induced the conversion of M1 macrophages to M2 macrophages, thus accelerating the maturation of the wound. By contrast, androgen supplementation enhanced the inflammatory response and prolonged the inflammatory phase. Moreover, the anti-inflammatory phase was delayed and weakened.
Androgen deprivation promotes re-epithelialization of the wound, regulates the inflammatory response, and accelerates wound healing of the prostatic urethra after a TmLRP. Prostate 77:708-717, 2017. © 2017 Wiley Periodicals, Inc.
铥激光前列腺切除术（TmLRP）后的并发症与前列腺尿道的重新上皮化有关。由于前列腺的生长发育由雄激素诱导，本研究旨在确定雄激素在前列腺尿道伤口愈合中的作用并探索其机制。
接受TmLRP的比格犬被随机分为去势组、十一酸睾酮（TU）组和对照组。每周使用膀胱镜评估前列腺伤口一次。然后进行组织学分析以研究每组前列腺尿道的重新上皮化情况。还对伤口组织和尿液中的炎症反应进行了研究。
与对照组相比，TmLRP后去势组前列腺尿道愈合更快，TU组更慢。去势通过促进伤口表面及伤口下方的基底细胞增殖以及加速基底细胞向尿路上皮细胞的分化来加速重新上皮化。去势缩短了炎症期持续时间，并诱导M1巨噬细胞向M2巨噬细胞转化，从而加速伤口成熟。相比之下，补充雄激素增强了炎症反应并延长了炎症期。此外，抗炎期延迟且减弱。
雄激素剥夺促进伤口重新上皮化，调节炎症反应，并加速TmLRP后前列腺尿道的伤口愈合。《前列腺》77:708 - 717, 2017。© 2017威利期刊公司。
