Biological Sciences, University of Southampton, Southampton, United Kingdom.
Stem Cells Transl Med. 2017 Jan;6(1):3-6. doi: 10.5966/sctm.2016-0026. Epub 2016 Sep 9.
This Perspective discusses some activities of mesenchymal stem cells (MSCs) in the context of angiogenesis, focusing on contrasting effects that could call into question the extent to which MSCs can be used clinically in the future. We report on the antiangiogenic/antiproliferative effects of specific MSC populations (including bone marrow MSCs), their paracrine activity, tissue heterogeneity, and endothelial cell interactions. Also discussed are what could lead to contrasting effects of the influence of MSCs in regulating angiogenesis, pointing to some negative effects of these cells. In conclusion, this article highlights important aspects of MSC behavior within the perspective of translational medicine applications. Stem Cells Translational Medicine 2017;6:3-6.
这篇观点文章讨论了间充质干细胞（MSCs）在血管生成背景下的一些活动，重点关注可能会质疑未来 MSCs 在临床应用程度的对比作用。我们报告了特定 MSC 群体（包括骨髓 MSCs）的抗血管生成/抗增殖作用、旁分泌活性、组织异质性和内皮细胞相互作用。同时还讨论了可能导致 MSCs 调节血管生成的影响产生对比作用的因素，指出这些细胞的一些负面影响。总之，本文从转化医学应用的角度强调了 MSC 行为的重要方面。《干细胞转化医学》2017;6:3-6。
