Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan, 750004, Ningxia, China.
The Center of Reproductive Medicine of General Hospital of Ningxia Medical University, Ningxia Medical University, No.804 Shengli Street, Yinchuan, 750004, Ningxia, China.
Stem Cell Res Ther. 2018 Oct 4;9(1):263. doi: 10.1186/s13287-018-1008-9.
With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs (BMSCs) improve the ovarian reserve, which mainly depends on homing and paracrine activities. Furthermore, paracrine factors secreted by these stem cells play an important role in ovarian recovery. Relevant studies indicate that BMSC transplantation has some positive effects on the treatment of POF in animals, but BMSCs are not widely applied in clinical therapy. Clinical trials are ongoing despite the fact that several patients experiencing BMSC transplantation recover their normal menstrual cycles and even give birth to babies. In this review, we discuss the possible therapeutic mechanisms of BMSCs for POF, migration, antiapoptosis, antifibrosis, angiogenesis, anti-inflammation, immunoregulation, and oxidative stress, which provide the theoretical basis for further study and clinical therapy.
随着再生医学的发展，越来越多的间充质干细胞（MSCs）被认为可用于治疗卵巢早衰（POF）。据报道，骨髓来源的间充质干细胞（BMSCs）可改善卵巢储备功能，主要依赖于归巢和旁分泌活性。此外，这些干细胞分泌的旁分泌因子在卵巢恢复中发挥重要作用。相关研究表明，BMSC 移植对动物 POF 的治疗有一定的积极作用，但 BMSCs 在临床治疗中并未得到广泛应用。尽管有几项 BMSC 移植的患者恢复了正常的月经周期，甚至生育了婴儿，但临床试验仍在进行中。在这篇综述中，我们讨论了 BMSCs 治疗 POF 的可能治疗机制，包括迁移、抗细胞凋亡、抗纤维化、血管生成、抗炎、免疫调节和氧化应激，为进一步的研究和临床治疗提供了理论依据。
