Department of Organic Chemistry, Weizmann Institute of Science , Rehovot 7610001, Israel.
J Am Chem Soc. 2017 Feb 15;139(6):2136-2139. doi: 10.1021/jacs.6b10809. Epub 2017 Feb 7.
Different amyloid beta (Aβ) aggregates can be discriminated by a combinatorial fluorescent molecular sensor. The unique optical fingerprints generated by the unimolecular analytical device provide a simple means to differentiate among aggregates generated from different alloforms or through distinct pathways. The sensor has also been used to track dynamic changes that occur in Aβ aggregation states, which result from the formation of low molecular weight oligomers, high molecular weight oligomers, protofibrils, and fibrils.
不同的淀粉样β（Aβ）聚集物可以通过组合荧光分子传感器来区分。单分子分析装置产生的独特光学指纹为区分来自不同同种型或通过不同途径产生的聚集物提供了一种简单的方法。该传感器还被用于跟踪 Aβ聚集状态的动态变化，这些变化是由低分子量寡聚物、高分子量寡聚物、原纤维和纤维的形成引起的。
