定义一种阶段特异性小鼠胚胎抗原（SSEA-1）的单克隆抗体。
Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
作者信息
Solter D, Knowles B B
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5565-9. doi: 10.1073/pnas.75.11.5565.
A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.
描述了一种通过将小鼠骨髓瘤细胞与用F9畸胎瘤细胞免疫的小鼠脾细胞融合而获得的单克隆抗体。这种抗体与小鼠和人源的胚胎癌细胞以及一些植入前阶段的小鼠胚胎发生反应，定义了一种胚胎阶段特异性抗原。这种阶段特异性抗原（SSEA-1）首先在8细胞阶段胚胎的卵裂球上被检测到。滋养外胚层细胞短暂呈阳性；然而，内细胞团中的每个细胞最终都会表达这种抗原。
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