Conner Jenna G, Zamorano-Sánchez David, Park Jin Hwan, Sondermann Holger, Yildiz Fitnat H
Department of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, CA, USA.
Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Curr Opin Microbiol. 2017 Apr;36:20-29. doi: 10.1016/j.mib.2017.01.002. Epub 2017 Feb 5.
The second messenger nucleotide cyclic dimeric guanosine monophosphate (c-di-GMP) governs many cellular processes in the facultative human pathogen Vibrio cholerae. This organism copes with changing environmental conditions in aquatic environments and during transitions to and from human hosts. Modulation of c-di-GMP allows V. cholerae to shift between motile and sessile stages of life, thus allowing adaptation to stressors and environmental conditions during its transmission cycle. The V. cholerae genome encodes a large set of proteins predicted to degrade and produce c-di-GMP. A subset of these enzymes has been demonstrated to control cellular processes - particularly motility, biofilm formation, and virulence - through transcriptional, post-transcriptional, and translational mechanisms. Recent studies have identified and characterized enzymes that modulate or sense c-di-GMP levels and have led towards mechanistic understanding of c-di-GMP regulatory circuits in V. cholerae.
第二信使核苷酸环二聚鸟苷单磷酸（c-di-GMP）调控着兼性人类病原体霍乱弧菌中的许多细胞过程。这种生物体应对水生环境中不断变化的环境条件，以及在进出人类宿主的转变过程中的环境条件。c-di-GMP的调节使霍乱弧菌能够在游动和固着生活阶段之间转换，从而在其传播周期中适应应激源和环境条件。霍乱弧菌基因组编码了大量预测可降解和产生c-di-GMP的蛋白质。这些酶的一个子集已被证明通过转录、转录后和翻译机制来控制细胞过程，特别是运动性、生物膜形成和毒力。最近的研究已经鉴定并表征了调节或感知c-di-GMP水平的酶，并朝着对霍乱弧菌中c-di-GMP调控回路的机制理解迈进。
