行为活性肽介导神经元相互作用的证据。
Evidence for mediation of a neuronal interaction by a behaviorally active peptide.
作者信息
Branton W D, Arch S, Smock T, Mayeri E
出版信息
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5732-6. doi: 10.1073/pnas.75.11.5732.
Abstract
Egg laying hormone, a peptide neurohormone with an approximate molecular weight of 6000, was isolated from the region of the abdominal ganglion of Aplysia that contains the neuroendocrine bag cells and purified by gel filtration chromatography, isoelectric focusing, and dialysis. A 1-min local application of egg laying hormone to the identified neuron R15 produced prolonged (greater than 1 hr) augmentation of impulse activity in this neuron. The distinctive quality and prolonged duration of the response are apparently identical to the previously described response to electrically elicited bag cell activity. The results provide evidence that egg laying hormone is the mediator of this prolonged neuronal interaction.
摘要
产卵激素是一种分子量约为6000的肽类神经激素，从海兔腹神经节中含有神经内分泌袋状细胞的区域分离出来，并通过凝胶过滤色谱法、等电聚焦法和透析法进行纯化。向已识别的神经元R15局部施加1分钟的产卵激素，可使该神经元的冲动活动延长（超过1小时）增强。这种反应的独特性质和延长的持续时间显然与先前描述的对电诱发袋状细胞活动的反应相同。这些结果提供了证据，表明产卵激素是这种延长的神经元相互作用的介质。
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