女性生殖道1期胚胎性横纹肌肉瘤：9例回顾性临床研究
Stage 1 embryonal rhabdomyosarcoma of the female genital tract: a retrospective clinical study of nine cases.
作者信息
Yuan Guangwen, Yao Hongwen, Li Xiaoguang, Li Hongjun, Wu Lingying
机构信息
Department of Gynecologic Oncology, Cancer Hospital of Peking Union Medical College and Chinese Academy of Medical Science, No 17 Panjiayuan South Street, Chaoyang District, Beijing, China.
出版信息
World J Surg Oncol. 2017 Feb 7;15(1):42. doi: 10.1186/s12957-017-1110-y.
BACKGROUND
The aim of the study is to investigate the clinical features, treatments, and prognosis of stage 1 embryonal rhabdomyosarcoma of the female genital tract.
METHODS
A retrospective analysis was performed on nine cases of stage 1 embryonal rhabdomyosarcoma of the female genital tract. Clinical characteristics, treatments, recurrence, and prognosis were analyzed.
RESULTS
Of the nine patients with embryonal rhabdomyosarcoma, three originated from the vagina and six from the cervix. For the eight patients who initially received surgery, the median survival time was 88 months. As for the six patients that received adjuvant chemotherapy, five of them who received six or more cycles of treatment achieved tumor-free survival and the survival time ranged from 9 to 228 months. The remaining patient, who declined further treatment after two cycles of chemotherapy, relapsed 11 months following the surgery and died 3 months later. Out of the nine patients, only one was initially treated with chemotherapy, and achieved complete remission, but relapsed 21 months later. After a combination of surgery and chemotherapy, this patient remained tumor-free for total of 117 months.
CONCLUSIONS
Patients with early stage embryonal rhabdomyosarcoma of the female genital tract have good prognosis, and the combination of surgery and chemotherapy can lead to better outcomes.
背景
本研究旨在探讨女性生殖道1期胚胎性横纹肌肉瘤的临床特征、治疗方法及预后。
方法
对9例女性生殖道1期胚胎性横纹肌肉瘤患者进行回顾性分析。分析其临床特征、治疗方法、复发情况及预后。
结果
9例胚胎性横纹肌肉瘤患者中，3例起源于阴道，6例起源于宫颈。8例最初接受手术治疗的患者，中位生存时间为88个月。6例接受辅助化疗的患者中，5例接受6个或更多周期治疗的患者实现了无瘤生存，生存时间为9至228个月。其余1例患者在两个周期化疗后拒绝进一步治疗，术后11个月复发，3个月后死亡。9例患者中，仅1例最初接受化疗并实现完全缓解，但21个月后复发。手术和化疗联合治疗后，该患者无瘤生存共计117个月。
结论
女性生殖道早期胚胎性横纹肌肉瘤患者预后良好，手术和化疗联合治疗可取得更好的效果。
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