Bindra D S, Wilson G S
Anal Chem. 1989 Nov 15;61(22):2566-70. doi: 10.1021/ac00197a022.
A nonenzymatic glucose sensor that utilizes permselective membranes to achieve the selectivity required for screening glucose in biological fluids has been described. Interference from endogenous oxidizable substances such as amino acids, urea, ascorbic acid, and uric acid, as well as the effect of chloride and proteins on glucose response, is studied by using flow injection analysis. A set of membranes made of Naflin perfluorinated membrane and collagen, when arranged in front of the working electrode (gold), result in significant improvement in the system selectivity. Even at physiological pH, which is far from being the optimum pH for pulsed amperometric detection of carbohydrates, the sensor shows a good limit of detection (4-5 micrograms of glucose injected).
已描述了一种非酶葡萄糖传感器，该传感器利用渗透选择性膜来实现筛选生物流体中葡萄糖所需的选择性。通过流动注射分析研究了内源性可氧化物质（如氨基酸、尿素、抗坏血酸和尿酸）的干扰，以及氯离子和蛋白质对葡萄糖响应的影响。一组由Naflin全氟膜和胶原蛋白制成的膜，当布置在工作电极（金）前面时，可显著提高系统的选择性。即使在生理pH值下（这远非脉冲安培法检测碳水化合物的最佳pH值），该传感器仍显示出良好的检测限（注入4-5微克葡萄糖）。
