Karaśkiewicz Joanna, Penkala Krzysztof, Mularczyk Maciej, Lubiński Wojciech
Department of Ophthalmology, Pomeranian Medical University, Powstańców Wielkopolskich 72 Str., Szczecin, Poland.
Department of Systems, Signals and Electronics Engineering, Faculty of Electrical Engineering, West Pomeranian University of Technology, Szczecin, Poland.
Doc Ophthalmol. 2017 Apr;134(2):89-97. doi: 10.1007/s10633-017-9575-0. Epub 2017 Feb 7.
To evaluate retinal ganglion cell (RGC) function after intraocular pressure (IOP) reduction measured by pattern electroretinogram (PERG) in patients with newly diagnosed, non-treated preperimetric and early stages of primary open-angle glaucoma (POAG).
Twenty-four eyes from 24 patients with POAG: 11 eyes with preperimetric glaucoma and 13 eyes with early glaucoma received Ganfort (bimatoprost + timolol) once a day for a period of 1 month. Before and after the treatment, following measurements were analyzed: IOP, mean ocular perfusion pressure (MOPP), peak time of P50 and amplitude of P50 and N95 waves in PERG (ISCEV standard 2012). Correlations between PERG P50 and N95 waves, IOP and MOPP were calculated.
After therapy, IOP significantly decreased in all eyes, on average 31%. Significant increase in MOPP in all eyes on average 14% was detected. PERG amplitude of P50 and N95 waves increased in 75 and 79% eyes, respectively, on average P50 by 28% and N95 by 38%. There were no significant interactions between the change of PERG parameters in time and stage of glaucoma.
Significant IOP-lowering therapy can improve RGC function measured by PERG, in patients with preperimetric and early stages of POAG.
通过图形视网膜电图（PERG）评估新诊断的未经治疗的视野缺损前期和原发性开角型青光眼（POAG）早期患者眼压降低后视网膜神经节细胞（RGC）的功能。
24例POAG患者的24只眼：11只视野缺损前期青光眼眼和13只早期青光眼眼，每天使用一次Ganfort（比马前列素+噻吗洛尔），持续1个月。治疗前后，分析以下测量指标：眼压、平均眼灌注压（MOPP）、PERG中P50的峰值时间以及P50和N95波的振幅（2012年国际临床视觉电生理学会标准）。计算PERG P50和N95波、眼压和MOPP之间的相关性。
治疗后，所有眼睛的眼压均显著降低，平均降低31%。检测到所有眼睛的MOPP平均显著增加14%。P50和N95波的PERG振幅分别在75%和79%的眼睛中增加，P50平均增加28%，N95平均增加38%。PERG参数变化与青光眼分期之间没有显著的相互作用。
显著降低眼压的治疗可以改善POAG视野缺损前期和早期患者通过PERG测量的RGC功能。
