Shirazian Shayan, Aina Olufemi, Park Youngjun, Chowdhury Nawsheen, Leger Kathleen, Hou Linle, Miyawaki Nobuyuki, Mathur Vandana S
Division of Nephrology, Department of Medicine, Winthrop University Hospital, Mineola, NY.
Mathur Consulting, Woodside, CA, USA.
Int J Nephrol Renovasc Dis. 2017 Jan 23;10:11-26. doi: 10.2147/IJNRD.S108045. eCollection 2017.
Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.
慢性肾脏病相关性瘙痒（CKD-aP）是慢性肾脏病和终末期肾病患者中一种令人痛苦且常被忽视的病症。它影响约40%的终末期肾病患者，并与生活质量差、睡眠不佳、抑郁及死亡率相关。基于用于诊断CKD-aP的工具，患病率估计值有所不同，因此迫切需要标准化的诊断工具。治疗研究结果常常相互矛盾。这可能与样本量小、设计有缺陷以及诊断工具不标准化所限制的研究有关。最近已经完成了几项设计良好的大型治疗试验，可能很快会对CKD-aP的管理产生影响。
