Chen Pan, Tan Rui-Zhi, Zhao Wen-Jing, Gao Jing, Wang Li, Su Hong-Wei, Liu Jian
Department of Nephrology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Research Center of Integrated Traditional Chinese and Western Medicine, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Medicine (Baltimore). 2025 May 30;104(22):e42628. doi: 10.1097/MD.0000000000042628.
Chronic kidney disease-associated pruritus (CKD-aP) is an itch directly associated with kidney disease. Currently, there is no bibliometric analysis literature in this field. Therefore, this study employs bibliometric methods to understand the characteristics, hotspots, and frontiers of global CKD-aP research in the past 20 years.
Publications relevant to CKD-aP, published from 2004 to 2023, were retrieved from the Science Citation Index-Expanded Web of Science Core Collection. Then, we used VOSviewer, CiteSpace, and Scimago Graphica software to construct visualization maps.
A total of 472 papers were retrieved. The author with the most published papers is Szepietowski (19 papers). Regarding institutions, the Medical University of Wroclaw (18 papers) has the highest publication output. The most prolific country is the United States (112 papers). The author with the highest number of citations is Pisoni RL (199 citations). Nephrology Dialysis Transplantation (401 citations) is the journal with the highest citation frequency. Cluster analysis of co-citation shows the largest cluster and current hotspot as "CKD-associated pruritus" (140 papers). The most frequently occurring keyword is "dialysis" (181 occurrences), and the keyword with the highest burst intensity is "skin" (5.75). Keywords related to the etiology and treatment of CKD-aP include "histamine," "naltrexone," and "gabapentin."
Exploring the definite etiology and mechanisms of CKD-aP and effective treatment methods are crucial research topics in the past and future. Additionally, this study provides a fresh perspective on the CKD-aP field, offering valuable insights for future research endeavors.
慢性肾脏病相关瘙痒（CKD-aP）是一种与肾脏疾病直接相关的瘙痒。目前，该领域尚无文献计量分析文献。因此，本研究采用文献计量方法来了解过去20年全球CKD-aP研究的特征、热点和前沿。
从科学引文索引扩展版的科学网核心合集中检索2004年至2023年发表的与CKD-aP相关的出版物。然后，我们使用VOSviewer、CiteSpace和Scimago Graphica软件构建可视化地图。
共检索到472篇论文。发表论文最多的作者是塞皮耶托夫斯基（19篇）。在机构方面，弗罗茨瓦夫医科大学（18篇）发表量最高。发文量最多的国家是美国（112篇）。被引次数最多的作者是皮索尼RL（199次）。《肾脏病透析移植》（401次）是被引频次最高的期刊。共被引聚类分析显示最大的聚类和当前热点为“CKD相关瘙痒”（140篇）。出现频率最高的关键词是“透析”（出现181次），爆发强度最高的关键词是“皮肤”（5.75）。与CKD-aP病因和治疗相关的关键词包括“组胺”、“纳曲酮”和“加巴喷丁”。
探索CKD-aP的确切病因和机制以及有效的治疗方法是过去和未来的关键研究课题。此外，本研究为CKD-aP领域提供了新的视角，为未来的研究工作提供了有价值的见解。
