通用的钌（II）催化苯甲酰胺的C-H氰化反应
Versatile ruthenium(II)-catalyzed C-H cyanations of benzamides.
作者信息
Liu Weiping, Ackermann Lutz
机构信息
Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany.
出版信息
Chem Commun (Camb). 2014 Feb 21;50(15):1878-81. doi: 10.1039/c3cc49502g. Epub 2014 Jan 9.
PMID:24402371
Abstract
Direct cyanations of arenes and heteroarenes bearing only weakly coordinating amides were accomplished using a robust ruthenium(II) catalyst. The user-friendly C(sp(2))-H activation occurred with the assistance of carboxylate with high site-selectivity, excellent functional group tolerance and ample scope.
摘要
使用一种稳定的钌（II）催化剂实现了仅带有弱配位酰胺的芳烃和杂芳烃的直接氰化反应。在羧酸盐的协助下，发生了用户友好型的C（sp(2)）-H活化反应，具有高位点选择性、出色的官能团耐受性和广泛的适用范围。
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