Crutcher K A, Privitera M
Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515.
Ann Neurol. 1989 Oct;26(4):580-3. doi: 10.1002/ana.410260414.
Fresh frozen sections of the temporal lobe from patients undergoing surgical resection for the control of epilepsy were used as a substrate in tissue culture to test for neurite growth-promoting activity. Robust neurite growth from ganglia of embryonic chicks was observed on gray matter regions of the sections and little growth was observed on white matter regions. These results indicate that the dichotomy between gray and white matter regions of the mature central nervous system in supporting neurite growth is present in human brain tissue and supports the general hypothesis that white matter in the mature central nervous system inhibits neurite regeneration but that gray matter will support neurite growth.
对因控制癫痫而接受手术切除的患者的颞叶新鲜冰冻切片进行组织培养，以此作为底物来测试其促进神经突生长的活性。在切片的灰质区域观察到来自胚胎小鸡神经节的强劲神经突生长，而在白质区域几乎没有观察到生长。这些结果表明，成熟中枢神经系统的灰质和白质区域在支持神经突生长方面的二分法在人类脑组织中存在，支持了这样一个普遍假设，即成熟中枢神经系统中的白质会抑制神经突再生，而灰质则会支持神经突生长。
