养育观察研究队列资料简介，该研究在美国东南部考察了多位照料者对婴儿生长的关联影响。
Cohort profile for the Nurture Observational Study examining associations of multiple caregivers on infant growth in the Southeastern USA.
机构信息
Department of Health, Behavior and Society, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.
出版信息
BMJ Open. 2017 Feb 8;7(2):e013939. doi: 10.1136/bmjopen-2016-013939.
PURPOSE
Childcare has been associated with obesity in children in cross-sectional and longitudinal studies, although some observed no association. Few studies have focused on care during infancy, a period when children may be especially vulnerable.
PARTICIPANTS
The Nurture Study is an observational birth cohort designed to assess longitudinal associations of childcare and the presence of multiple caregivers on infant adiposity and weight trajectories throughout the first year of life. We examine as potential mediators feeding, physical activity, sleep and stress. We completed recruitment in 2015. Of the 860 women who enrolled during pregnancy, 799 delivered a single live infant who met our inclusion criteria. Of those, 666 mothers (77.4%) agreed to participate in the study for themselves and their infants.
FINDINGS TO DATE
Among the 666 women in the study, 472 (71%) identified as black, 127 (19%) as white, 7 (1%) as Asian or Asian American, 6 (1%) as Native American and 49 (7%) as other race or more than one race; 43 (7%) identified as Hispanic/Latina. Just under half (48%) had a high school diploma or less, 61% had household incomes <$20 000/year and 59% were married or living with a partner. The mean (SD) infant gestational age was 41.28 weeks (2.29) and birth weight for gestational age z-score was -0.31 (0.93). Just under half (49%) of infants were females, 69% received some human milk and 40% were exclusively breast fed at hospital discharge. Data collection began in 2013, is currently underway, and is scheduled to conclude in late 2016.
FUTURE PLANS
Results will help assess the magnitude of associations between childcare in infancy and subsequent obesity. Findings will also inform intervention and policy efforts to improve childcare environments and help prevent obesity in settings where many infants spend time.
TRIAL REGISTRATION NUMBER
Clinicaltrials.gov, NCT01788644.
目的
儿童保育与横断面和纵向研究中儿童肥胖有关，尽管一些研究没有发现关联。很少有研究关注婴儿期的保育，因为在这个时期，儿童可能特别容易受到影响。
参与者
“培育研究”是一项观察性出生队列研究，旨在评估婴儿期保育以及存在多个照顾者对婴儿肥胖和体重轨迹的纵向关联，整个生命的第一年。我们研究了作为潜在中介的喂养、身体活动、睡眠和压力。我们于 2015 年完成了招募。在怀孕期间登记的 860 名女性中，有 799 名分娩了符合我们纳入标准的单一活婴。其中，666 名母亲（77.4%）同意为自己和婴儿参与研究。
迄今为止的发现
在研究中的 666 名女性中，472 名（71%）认定为黑人，127 名（19%）认定为白人，7 名（1%）认定为亚洲或亚裔美国人，6 名（1%）认定为美国原住民，49 名（7%）认定为其他种族或多种族；43 名（7%）认定为西班牙裔/拉丁裔。略低于一半（48%）有高中文凭或以下，61%的家庭收入<$20000/年，59%已婚或与伴侣同居。婴儿的平均（SD）胎龄为 41.28 周（2.29），胎龄体重 z 分数为-0.31（0.93）。略低于一半（49%）的婴儿为女性，69%接受了一些人乳，40%在医院出院时纯母乳喂养。数据收集始于 2013 年，目前正在进行中，并计划于 2016 年末结束。
未来计划
结果将有助于评估婴儿期保育与随后肥胖之间关联的程度。研究结果还将为改善保育环境的干预和政策努力提供信息，并帮助在许多婴儿逗留的环境中预防肥胖。
试验注册
Clinicaltrials.gov，NCT01788644。
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