Rodriguez-Urrego Paula A, Dulcey-Hormiga Isabel C, Barrera-Herrera Luis E, Suarez-Zamora David A, Palau-Lazaro Mauricio A, Buritica-Cifuentes Catalina
Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Colombia; School of Medicine, Universidad de los Andes, Colombia.
Department of Pathology and Laboratories, Hospital Universitario Fundación Santa Fe de Bogotá, Colombia.
J Cytol. 2017 Jan-Mar;34(1):61-63. doi: 10.4103/0970-9371.197624.
Endometriosis involving the uterine cervix is a rare condition that can lead to diagnostic errors in the interpretation of Pap smear. We report the case of a 41-year-old patient in whom the initial Pap smear revealed three-dimensional clusters of glandular cells with elongated nuclei, occasional mitosis, and atypia, which was interpreted as atypical glandular cells, not otherwise specified (NOS). The patient was taken to colposcopy and endocervical biopsy. Colposcopy was normal and the biopsy presented glands with elongated nuclei and surrounded by endometrial stroma admixed with normal endocervical glands. Immunohistochemical studies were reactive for CD10 in the stromal cells and vimentin in endometrioid glands. The findings were consistent with cervical endometriosis. Endometriosis in the cervix is an uncommon pathology that mimics malignancy and may be interpreted as atypical or glandular neoplasia in the cytology.
累及子宫颈的子宫内膜异位症是一种罕见疾病，可导致巴氏涂片解读出现诊断错误。我们报告一例41岁患者，其最初的巴氏涂片显示腺细胞呈三维簇状，核拉长，偶见有丝分裂及异型性，被解读为不典型腺细胞，非特殊类型（NOS）。该患者接受了阴道镜检查及宫颈管活检。阴道镜检查正常，活检显示腺体核拉长，周围有子宫内膜间质，并混有正常宫颈管腺体。免疫组化研究显示间质细胞中CD10呈阳性，子宫内膜样腺体中波形蛋白呈阳性。这些发现符合宫颈子宫内膜异位症。宫颈子宫内膜异位症是一种罕见的病理情况，可酷似恶性肿瘤，在细胞学检查中可能被解读为非典型或腺性肿瘤。
