Fu Zhiyi, Hu Xiaopeng, Wu Yujie, Zhou Zihui
Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai City, China.
Department of Orthopaedics, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai City, China.
Dose Response. 2016 Dec 20;14(4):1559325816682867. doi: 10.1177/1559325816682867. eCollection 2016 Oct-Dec.
The aim of this study was to determine if there were dose-response relationships of cement volume with cement leakage and pain relief after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs). We collected the patient and procedural characteristics on 108 patients with OVCFs in our hospital who received PVP. Univariate and multivariate analyses were performed to explore the relationships between these potential influential variables and cement leakage and pain relief at 1 month postoperatively. Multivariate linear and logistic regression analyses were conducted with the pain score reduction and the bone cement leakage as dependent variables and the potential risk factors as independent variables, respectively. The results showed that the independent risk factors for the pain relief were the cement volume injected and fracture age, and for bone cement leakage were the cement volume injected and low-viscosity cement. In conclusion, the present study indicated that there were positive dose-response correlation relationships of cement volume with the incidence of cement leakage and the degree of pain relief after PVP, respectively. Thus, the cement should be injected into the vertebrae as much as possible during the PVP procedure.
本研究的目的是确定在经皮椎体成形术（PVP）治疗骨质疏松性椎体压缩骨折（OVCFs）后，骨水泥体积与骨水泥渗漏及疼痛缓解之间是否存在剂量反应关系。我们收集了我院108例接受PVP治疗的OVCFs患者的患者及手术特征。进行单因素和多因素分析，以探讨这些潜在影响变量与术后1个月时骨水泥渗漏及疼痛缓解之间的关系。分别以疼痛评分降低和骨水泥渗漏为因变量，以潜在危险因素为自变量，进行多因素线性和逻辑回归分析。结果显示，疼痛缓解的独立危险因素为注入的骨水泥体积和骨折时间，骨水泥渗漏的独立危险因素为注入的骨水泥体积和低粘度骨水泥。总之，本研究表明，PVP术后骨水泥体积分别与骨水泥渗漏发生率和疼痛缓解程度呈正剂量反应相关关系。因此，在PVP手术过程中应尽可能多地将骨水泥注入椎体内。
