Kaufmann T J, Trout A T, Kallmes D F
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
AJNR Am J Neuroradiol. 2006 Oct;27(9):1933-7.
There exists significant variability in the volume of polymethylmethacrylate cement injected during percutaneous vertebroplasty. Larger cement volumes injected may be associated with better clinical outcomes, but larger volumes may also be associated with greater risk of complications related to cement leakage. We describe an analysis of the association between clinical and procedural variables, including cement volume injected, and the clinical outcomes of patients treated with single-level vertebroplasty.
Retrospective analysis of 158 patients treated with single-level vertebroplasty was performed. Relationships among patient and procedural variables and relationships between these variables and ordinal clinical outcome scores of pain and medication use at postprocedure time points from 1 week to 2 years were evaluated with bivariate and multivariable analyses.
There was no significant association between the volume of cement injected and the clinical outcomes of postprocedure pain (P = .159-.871) and medication use (P = .223-.875).
Vertebroplasty operators need not feel compelled to achieve particular cement volumes injected in the pursuit of better clinical outcomes but should strive to achieve the maximal safe filling of individual vertebral bodies.
经皮椎体成形术中注入的聚甲基丙烯酸甲酯骨水泥体积存在显著差异。注入较大体积的骨水泥可能与更好的临床结果相关，但较大体积也可能与骨水泥渗漏相关并发症的风险增加有关。我们描述了一项关于临床和手术变量（包括注入的骨水泥体积）与接受单节段椎体成形术患者临床结果之间关联的分析。
对158例行单节段椎体成形术的患者进行回顾性分析。采用双变量和多变量分析评估患者和手术变量之间的关系，以及这些变量与术后1周~2年各时间点疼痛和药物使用的有序临床结果评分之间的关系。
注入的骨水泥体积与术后疼痛的临床结果（P = 0.159 - 0.871）和药物使用（P = 0.223 - 0.875）之间无显著关联。
椎体成形术操作者不必为追求更好的临床结果而执意注入特定体积的骨水泥，而应努力实现单个椎体的最大安全填充。
