Bento-Bernardes Thais, Toste Fernanda P, Pazos-Moura Carmen C, Oliveira Karen J
Departamento de Fisiologia e Farmacologia, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
J Sci Food Agric. 2017 Aug;97(11):3855-3863. doi: 10.1002/jsfa.8253. Epub 2017 Mar 10.
Cinnamon supplementation has been associated with an improvement in glucose disposal and a reduction in fat mass in type 2 diabetes. Maternal nutrition during lactation impacts the health of the offspring throughout life. We hypothesize that cinnamon intake by lactating rats affects maternal physiology, leading to hormonal and metabolic changes in their offspring. To investigate this hypothesis, dams received aqueous cinnamon extract (400 mg cinnamon kg body mass day ) or water orally, during lactation.
Maternal cinnamon intake did not affect the body mass gain or food intake of dams or their offspring, although it decreased visceral white adipose tissue mass in dams and in their adult offspring of both sexes. Cinnamon-treated dams exhibited no differences in serum insulin, adiponectin, leptin or estradiol levels, although they presented higher serum progesterone. At weaning, cinnamon male pups exhibited lower insulinemia, whereas cinnamon female pups exhibited lower glycemia. Interestingly, in adulthood, only the female offspring exhibited an altered hormonal profile, with reduced serum leptin, adiponectin and insulin levels accompanied by lower glycemia.
The present study demonstrates that maternal cinnamon intake during lactation promotes mild changes in dams and can trigger sex-specific metabolic programming in pups that lasts into adulthood. © 2017 Society of Chemical Industry.
补充肉桂与改善2型糖尿病患者的葡萄糖代谢及减少脂肪量有关。哺乳期的母体营养会影响子代一生的健康。我们推测，哺乳期大鼠摄入肉桂会影响母体生理，导致其子代出现激素和代谢变化。为了验证这一推测，在哺乳期，母鼠经口给予肉桂水提取物（400毫克肉桂/千克体重/天）或水。
母体摄入肉桂虽可降低母鼠及其成年雌雄子代的内脏白色脂肪组织量，但不影响母鼠及其子代的体重增加或食物摄入量。经肉桂处理的母鼠血清胰岛素、脂联素、瘦素或雌二醇水平无差异，但其血清孕酮水平较高。断奶时，肉桂组雄性幼鼠的胰岛素血症较低，而肉桂组雌性幼鼠的血糖较低。有趣的是，成年后，只有雌性子代的激素谱发生改变，血清瘦素、脂联素和胰岛素水平降低，同时血糖也较低。
本研究表明，哺乳期母鼠摄入肉桂可使母鼠发生轻微变化，并可在幼鼠中引发持续至成年的性别特异性代谢编程。©2017化学工业协会。
