Food Research Department, School of Chemistry, Universidad Autonoma de Coahuila, 25280, Saltillo, Coahuila, Mexico.
Mini Rev Med Chem. 2018;18(15):1244-1252. doi: 10.2174/1389557517666170208144742.
The ellagitannins are a group of phenolic compounds with biological activities. Ellagic acid is the product obtained from hydrolysis of ellagitannins. Information related to the biosynthesis of ellagitannins still been scarce and confused. The ellagitannins are obtained from plants and their purification process implies mainly the use of chromatographic techniques. The ellagitannin acyl hydrolase (EAH) also known as ellagitannase is an enzyme capable of hydrolyzing the ester bonds of ellagitannins and the consequent releasing of ellagic acid. Information about the EAH is not clear because the enzyme had showed different activities due to the low purity or complexity of substrates and there is no available information about the biochemical, physicochemical and molecular characteristics of EAH. The present review describes information related to the sources, biosynthesis and the purification of ellagitannins and a current assessment on the production of ellagitannase.
鞣花单宁是一类具有生物活性的酚类化合物。鞣酸是从鞣花单宁水解得到的产物。鞣花单宁生物合成的信息仍然很少且混乱。鞣花单宁存在于植物中，其纯化过程主要涉及使用色谱技术。鞣花单宁酰基水解酶（EAH），也称为鞣花单宁酶，是一种能够水解鞣花单宁酯键并释放鞣酸的酶。关于 EAH 的信息尚不清楚，因为由于低纯度或复杂的底物，酶表现出不同的活性，并且没有关于 EAH 的生化、物理化学和分子特性的可用信息。本文综述了鞣花单宁的来源、生物合成和纯化方面的信息，并对鞣花单宁酶的生产进行了评估。
