Smart Y C, Rogers K M, Brien J H, Stewart J F, Burton R C
Discipline of Surgical Science, University of Newcastle, New South Wales.
Aust N Z J Surg. 1989 Oct;59(10):805-9. doi: 10.1111/j.1445-2197.1989.tb07013.x.
Blood from 1497 women who were either non-pregnant, pregnant at all stages of gestation, lactating after parturition, postmenopausal, or who had benign breast lumps, primary breast cancer or advanced breast cancer were tested for their peripheral blood mammary serum antigen (MSA), using the 3E1.2 monoclonal antibody (MoAb) in an inhibition enzyme linked immunosorbent assay test system. The study aimed to establish normal ranges for comparison with MSA levels in breast cancer and benign breast disease. Compared with normal premenopausal women, which included women measured 8-10 times throughout their menstrual cycle, circulating MSA levels were significantly elevated throughout pregnancy (P less than 0.0001), in postmenopausal women (P less than 0.05), in women with primary breast cancer (P less than 0.05) and women with advanced (metastatic) breast cancer (P less than 0.0001). As a group, the 30 women with benign breast disease did not demonstrate significantly different MSA level from normal. However, 3% of the group did have levels above the 'cut off' for normal (400 IU/mL). Analysis of the normal premenopausal women according to age, parity and stage of the menstrual cycle and during lactation showed that these parameters did not affect MSA levels. It is concluded that the test is potentially valuable in the detection of metastatic but not primary breast cancer, and the effects of pregnancy and postmenopausal status on the circulating MSA levels need to be considered in the interpretation of MSA measurements.
对1497名女性的血液进行检测，这些女性分别处于非孕期、妊娠各阶段、产后哺乳期、绝经后，或患有乳腺良性肿块、原发性乳腺癌或晚期乳腺癌，采用3E1.2单克隆抗体（MoAb），在抑制酶联免疫吸附试验检测系统中检测其外周血乳腺血清抗原（MSA）。该研究旨在确定正常范围，以便与乳腺癌和乳腺良性疾病中的MSA水平进行比较。与正常绝经前女性（包括在整个月经周期测量8 - 10次的女性）相比，妊娠期间（P小于0.0001）、绝经后女性（P小于0.05）、原发性乳腺癌女性（P小于0.05）和晚期（转移性）乳腺癌女性（P小于0.0001）的循环MSA水平均显著升高。作为一个群体，30名患有乳腺良性疾病的女性的MSA水平与正常女性相比没有显著差异。然而，该群体中有3%的女性MSA水平高于正常“临界值”（400 IU/mL）。根据年龄、胎次、月经周期阶段以及哺乳期对正常绝经前女性进行分析，结果显示这些参数不会影响MSA水平。研究得出结论，该检测在检测转移性乳腺癌而非原发性乳腺癌方面可能具有价值，并且在解释MSA测量结果时需要考虑妊娠和绝经后状态对循环MSA水平的影响。
