Tjandra J J, Russell I S, Collins J P, Stacker S A, McKenzie I F
Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Br J Surg. 1988 Aug;75(8):811-7. doi: 10.1002/bjs.1800750830.
A monoclonal antibody (3E1.2) based serum test using an enzyme immunoassay has been used to determine circulating levels of the breast cancer associated antigen--mammary serum antigen (MSA). Of 157 patients with early breast cancer (stage I and II) and 199 patients with advanced breast cancer (stage III and IV), 73 per cent and 87 per cent respectively had elevated MSA levels (i.e. greater than 300 inhibition units (IU). Furthermore, 40 of 44 patients (91 per cent) had a significant fall of MSA levels with reduction in tumour load by mastectomy. In addition, there was a correlation of MSA levels with the clinical course: changes in MSA levels correlated with changes in disease status (progressive disease, stable disease, disease regression) in 54 of 61 patients and antedated disease progression or recurrence by up to 8 months in some patients; and in 32 of 36 patients (89 per cent) with no clinical evidence of recurrence MSA levels did not vary by more than 25 per cent of the original MSA value over a period of 2-15 months. MSA is therefore a useful tumour marker in the diagnosis and staging of breast cancer. There is also evidence that serial estimations of MSA levels may be used to detect subclinical recurrence and the fluctuations in MSA levels might be useful in assessing response to therapy. Furthermore, it was also noted that surgical procedures such as fine needle aspiration biopsy or incisional biopsy could lead to a rise in MSA levels.
一种基于单克隆抗体（3E1.2）的血清检测方法，采用酶免疫测定法来测定乳腺癌相关抗原——乳腺血清抗原（MSA）的循环水平。在157例早期乳腺癌患者（I期和II期）和199例晚期乳腺癌患者（III期和IV期）中，分别有73%和87%的患者MSA水平升高（即大于300抑制单位（IU））。此外，44例患者中有40例（91%）在进行乳房切除术后肿瘤负荷降低，MSA水平显著下降。另外，MSA水平与临床病程存在相关性：61例患者中有54例MSA水平的变化与疾病状态（疾病进展、病情稳定、疾病消退）的变化相关，在一些患者中，MSA水平的变化比疾病进展或复发提前多达8个月；在36例无临床复发证据的患者中，有32例（89%）在2至15个月的时间内，MSA水平的变化不超过原始MSA值的25%。因此，MSA是乳腺癌诊断和分期中一种有用的肿瘤标志物。也有证据表明，对MSA水平进行系列测定可用于检测亚临床复发，MSA水平的波动可能有助于评估治疗反应。此外，还注意到细针穿刺活检或切开活检等外科手术可能导致MSA水平升高。
