Ma Xiaoe, Zhou Naizhen, Zhang Tianzhu, Hu Wanjun, Gu Ning
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Sipailou 2, Nanjing 210096, China; Research Institute of Southeast University in Suzhou, Ren Ai Road 150, Suzhou Industrial Park, Suzhou 215123, China.
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Sipailou 2, Nanjing 210096, China; Research Institute of Southeast University in Suzhou, Ren Ai Road 150, Suzhou Industrial Park, Suzhou 215123, China.
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:357-365. doi: 10.1016/j.msec.2016.12.039. Epub 2016 Dec 11.
Self-healing materials are of interest for drug delivery, cell and gene therapy, tissue engineering, and other biomedical applications. In this work, on the base of biocompatible polymer poly(methyl vinyl ether-alt-maleic acid) (P(MVE-alt-MA)), host polymer β-cyclodextrin-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-β-CD) and guest polymer adamantane-grafted P(MVE-alt-MA) (P(MVE-alt-MA)-g-Ad) were first prepared. Then through taking advantage of the traditional host-guest interaction of β-cyclodextrin and adamantane, a novel self-healing pH-sensitive physical P(MVE-alt-MA)-g-β-CD/P(MVE-alt-MA)-g-Ad supramolecular hydrogels were obtained after simply mixing the aqueous solution of host polymer and guest polymer. This kind of supramolecular hydrogels not only possess pH-sensitivity, but also possess the ability to repair themselves after being damaged.
自修复材料在药物递送、细胞和基因治疗、组织工程以及其他生物医学应用方面具有吸引力。在这项工作中，基于生物相容性聚合物聚（甲基乙烯基醚-alt-马来酸）（P(MVE-alt-MA)），首先制备了主体聚合物β-环糊精接枝的P(MVE-alt-MA)（P(MVE-alt-MA)-g-β-CD）和客体聚合物金刚烷接枝的P(MVE-alt-MA)（P(MVE-alt-MA)-g-Ad）。然后，利用β-环糊精与金刚烷的传统主客体相互作用，将主体聚合物和客体聚合物的水溶液简单混合后，得到了一种新型的自修复pH敏感物理P(MVE-alt-MA)-g-β-CD/P(MVE-alt-MA)-g-Ad超分子水凝胶。这种超分子水凝胶不仅具有pH敏感性，而且在受损后还具有自我修复的能力。
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