Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Meilong Road No. 130, Shanghai 200237, People's Republic of China.
Biomater Sci. 2020 Jun 21;8(12):3359-3369. doi: 10.1039/d0bm00290a. Epub 2020 May 6.
Supramolecular hydrogels based on host-guest interactions have drawn considerable attention due to their unique properties and promising applications. However, it is still a great challenge to construct supramolecular hydrogels that simultaneously achieve mechanical strength, processability, and biocompatibility. Herein, we present a rational design of a "supramolecular crosslinker" approach to fabricate a new host-guest hydrogel with super-stretchability, self-healing, and injectable properties and excellent biocompatibility. The star-shaped supramolecular crosslinker is formed by the host-guest interactions between octa-cyclodextrin polyhedral oligomeric silsesquioxane (OCDPOSS) and acrylamide-modified adamantane (Ad-AAm). Supramolecular hydrogels can be briefly prepared by UV-initiated copolymerization of acrylamide and supramolecular crosslinkers. Supramolecular hydrogels present impressive mechanical properties due to rigid POSS as the core of the supramolecular crosslinker. Moreover, multivalent host-guest interactions improve the ductility, rapid self-healing and injectable ability of these hydrogels. Simultaneously, these supramolecular hydrogels possess good biocompatibility and can be utilized as carriers for the sustained release of hydrophobic drugs. Thus, such supramolecular hydrogels will have potential applications for tissue engineering and drug delivery systems.
基于主客体相互作用的超分子水凝胶由于其独特的性质和广阔的应用前景而受到广泛关注。然而，构建同时具有机械强度、加工性能和生物相容性的超分子水凝胶仍然是一个巨大的挑战。在此，我们提出了一种“超分子交联剂”的合理设计方法，用于制备具有超拉伸性、自修复性、可注射性和优异生物相容性的新型主客体水凝胶。星形超分子交联剂是通过八面体笼型聚倍半硅氧烷（OCDPOSS）和丙烯酰胺修饰的金刚烷（Ad-AAm）之间的主客体相互作用形成的。超分子水凝胶可以通过丙烯酰胺和超分子交联剂的紫外光引发共聚反应简单制备。超分子水凝胶由于刚性 POSS 作为超分子交联剂的核心而呈现出令人印象深刻的机械性能。此外，多价主客体相互作用提高了这些水凝胶的延展性、快速自修复和可注射能力。同时，这些超分子水凝胶具有良好的生物相容性，可用作疏水性药物的缓释载体。因此，这种超分子水凝胶在组织工程和药物输送系统中有潜在的应用。
