Woodard B H, Ideker R E, Johnston W W
Acta Cytol. 1978 Sep-Oct;22(5):350-2.
This case illustrates the diagnosis of malignant melanoma from a sample of urine by cytologic examination without prior knowledge of cutaneous malignant melanoma and in the absence of chemical melanuria. The exfoliated cells were large, oval and solitary. They contained large, vesicular, sharply defined, often regularly contoured, eccentric nuclei with red macronucleoli. Their cytoplasm was cyanophilic with granular, brown-black pigment that histochemically was melanin. These composite characteristics, distinctive for malignant melanoma, eliminated other diagnostic possibilities. Surgical management was guided by an accurate cytologic diagnosis. The report emphasizes the clinical usefulness and criteria for accurate cytologic detection of metastatic malignant melanoma in urine.
本病例展示了在事先不知道皮肤恶性黑色素瘤且无化学性黑尿的情况下，通过细胞学检查从尿液样本中诊断恶性黑色素瘤。脱落细胞大、呈椭圆形且单个存在。它们含有大的、泡状的、边界清晰、轮廓通常规则的偏心核，带有红色大核仁。其细胞质嗜碱性，含有颗粒状的棕黑色色素，组织化学显示为黑色素。这些恶性黑色素瘤特有的综合特征排除了其他诊断可能性。手术治疗以准确的细胞学诊断为指导。该报告强调了尿液中转移性恶性黑色素瘤准确细胞学检测的临床实用性和标准。
