Masubuchi S, Nagai I, Hirata M, Kubo H, Masubuchi K
Acta Cytol. 1975 Nov-Dec;19(6):527-32.
Four cases of primary malignant melanoma of the vagina are described and discussed with respect to vaginal smears. Two cases treated with radiotherapy began to increase the amount of the melanin pigment during the course of irradiation. Characteristic cytologic features found in the four cases are summarized as follows: a) Distribution of cell 1) Scattering, no tendency of grouping 2) Moderate anisocytosis and anisokaryosis b) Cytoplasm 1) Cyanophilic wispy cytoplasm 2) Indistinct cytoplasmic rim 3) Relatively clear cytoplasm 4) Relatively low N/C ratio c) Melanin pigment 1) In melanoma cells-finely granular and diffusely packed in cytoplasm 2) In histiocytes-coarsely granular and densely packed in cytoplasm d) Nucleus 1) Extremely eccentric nucleus 2) Thin and irregular nuclear membrane 3) Relatively regular chromatin distribution 4) Finely or moderately granular chromatin pattern 5) Prominent nucleolus 6) Giant malignant cells (3-4 nuclei) 7) Intranuclear vacuole (punched out).
本文描述了4例原发性阴道恶性黑色素瘤，并结合阴道涂片进行讨论。2例接受放疗的患者在放疗过程中黑色素沉着量开始增加。这4例患者中发现的特征性细胞学特征总结如下：a)细胞分布：1)散在分布，无聚集倾向；2)中度细胞大小不等和核大小不等。b)细胞质：1)嗜碱性纤细细胞质；2)细胞质边缘不清晰；3)细胞质相对透明；4)核质比相对较低。c)黑色素：1)黑色素瘤细胞内——细颗粒状，弥漫分布于细胞质中；2)组织细胞内——粗颗粒状，密集分布于细胞质中。d)细胞核：1)核极度偏心；2)核膜薄且不规则；3)染色质分布相对规则；4)细颗粒状或中度颗粒状染色质模式；5)核仁明显；6)巨大恶性细胞(3 - 4个核)；7)核内空泡(穿孔状)。
