Holmquist N D, Torres J
Department of Pathology, Louisiana State University School of Medicine, New Orleans 70112.
Acta Cytol. 1988 Mar-Apr;32(2):252-6.
A malignant melanoma of the cervix, a rare neoplasm, was found to have an unusual cytologic pattern, similar to that of a leiomyosarcoma. A biopsy sample was diagnosed as cervical malignant melanoma of the spindle cell type. Some neoplastic cells in the tissue contained melanin pigment, whereas none of the abnormal cells in the cervical scrapes, except for an abnormal giant cell, had visible cytoplasmic pigment. The abnormal cells in the cervical scrape specimen were spindle-shaped, as were their nuclei, which is why the cytologic pattern was interpreted as that of a leiomyosarcoma. Evidence from this and previously reported cases shows that malignant melanoma must be considered as a possible source of exfoliated abnormal nonpigmented spindle-shaped cells in a cervicovaginal cell sample.
宫颈恶性黑色素瘤是一种罕见的肿瘤，其细胞形态学表现异常，类似于平滑肌肉瘤。一份活检样本被诊断为梭形细胞型宫颈恶性黑色素瘤。组织中的一些肿瘤细胞含有黑色素，而宫颈刮片中除一个异常巨细胞外，其余异常细胞均无可见的胞质色素。宫颈刮片标本中的异常细胞呈梭形，细胞核也呈梭形，这就是为什么细胞形态学表现被解释为平滑肌肉瘤。来自本病例及先前报道病例的证据表明，在宫颈阴道细胞样本中，恶性黑色素瘤必须被视为脱落的异常无色素梭形细胞的可能来源。
