Wang Shuai, Zhan Yajing, Zhang Yan, Lv Luxian, Wu Renrong, Zhao Jingping, Guo Wenbin
Hunan Key Laboratory of Psychiatry and Mental Health, Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders, No. 139, Middle Renming Road, Changsha, 410011, People's Republic of China.
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Eur Child Adolesc Psychiatry. 2017 Jul;26(7):839-845. doi: 10.1007/s00787-017-0958-2. Epub 2017 Feb 9.
Structural and functional abnormalities were reported in the brain of patients with adolescent-onset schizophrenia (AOS). However, evidence of abnormal functional connectivity of the brain in AOS patients is limited. Thus, we analyzed the resting-state functional magnetic resonance scans of 48 drug-naive AOS patients and 31 healthy controls to determine their functional connectivity strength (FCS) and examined if FCS abnormalities were correlated with clinical characteristics. Compared with healthy controls, AOS patients showed significantly increased FCS in the left cerebellum VI and right inferior frontal gyrus/insula. A positive correlation was observed between FCS values in the right inferior frontal gyrus/insula and general psychopathology scores of positive and negative syndrome scale. Results suggest that functional connectivity pattern is disrupted in drug-naive AOS patients. The FCS values in this abnormal region have potential for evaluating the disease severity.
据报道，青少年期起病的精神分裂症（AOS）患者大脑存在结构和功能异常。然而，AOS患者大脑功能连接异常的证据有限。因此，我们分析了48例未用药的AOS患者和31名健康对照者的静息态功能磁共振扫描结果，以确定其功能连接强度（FCS），并检查FCS异常是否与临床特征相关。与健康对照相比，AOS患者左侧小脑VI和右侧额下回/脑岛的FCS显著增加。右侧额下回/脑岛的FCS值与阳性和阴性症状量表的总体精神病理学评分之间存在正相关。结果表明，未用药的AOS患者的功能连接模式受到破坏。该异常区域的FCS值具有评估疾病严重程度的潜力。
