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Biochem J. 1989 Aug 15;262(1):173-80. doi: 10.1042/bj2620173.
2
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(23S)-1,23,25-Trihydroxyvitamin D3: its biologic activity and role in 1 alpha,25-dihydroxyvitamin D3 26,23-lactone biosynthesis.（23S）-1,23,25-三羟基维生素D3：其生物学活性及在1α,25-二羟基维生素D3 26,23-内酯生物合成中的作用。
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Chemical synthesis of [1 beta-3H] 1 alpha, 25-dihydroxyvitamin D3 and [1 alpha-3H] 1 beta, 25-dihydroxyvitamin D2: biological activity of 1 beta, 25-dihydroxyvitamin D3.[1β-³H]1α,25-二羟基维生素D3和[1α-³H]1β,25-二羟基维生素D2的化学合成：1β,25-二羟基维生素D3的生物活性
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1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.1,25-二羟基维生素D3可增加骨肉瘤细胞中维生素K依赖性骨蛋白的合成。
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C(24)- and C(23)-oxidation, converging pathways of intestinal 1,25-dihydroxyvitamin D3 metabolism: identification of 24-keto-1,23,25-trihydroxyvitamin D3.
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Chromatographic separation of 24(R),25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3-26,23-lactone using a cyano-bonded phase packing.使用氰基键合相填料对24(R),25-二羟基维生素D3和25-羟基维生素D3-26,23-内酯进行色谱分离。
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Calcium transport in perfused duodena from normal chicks: enhancement within fourteen minutes of exposure to 1,25-dihydroxyvitamin D3.正常雏鸡灌注十二指肠中的钙转运：暴露于1,25 - 二羟基维生素D3后十四分钟内增强。
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1,25-二羟维生素D3向钙三醇酸的靶细胞代谢。肾脏和骨骼中涉及24-氧化途径的证据。

Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation.

作者信息

Makin G, Lohnes D, Byford V, Ray R, Jones G

机构信息

Department of Biochemistry, Queen's University, Kingston, Ontario, Canada.

出版信息

Biochem J. 1989 Aug 15;262(1):173-80. doi: 10.1042/bj2620173.

DOI:10.1042/bj2620173
PMID:2818561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1133244/
Abstract

1,25-dihydroxyvitamin D3 is converted to calcitroic acid before being excreted in the bile. Biosynthesis of calcitroic acid has been demonstrated in two target cells of vitamin D, in the kidney and the osteoblastic cell line UMR-106. Calcitroic acid was identified by combinations of h.p.l.c., u.v. spectroscopy and mass spectrometry. Evidence is presented that calcitroate is derived from the 24-oxidation pathway, possibly through the intermediate 24,25,26,27-tetranor-1,23-dihydroxyvitamin D3. The 24-oxidation pathway to calcitroic acid in bone cells is stimulated by 1,25-dihydroxyvitamin D3. The pathway in both bone cells and perfused kidney operates at physiological concentrations of substrate and appears to be capable of rapid clearance of the hormone.

摘要

1,25-二羟基维生素D3在经胆汁排泄之前会转化为钙三醇酸。在维生素D的两个靶细胞（肾脏和成骨细胞系UMR-106）中已证实了钙三醇酸的生物合成。通过高效液相色谱、紫外光谱和质谱联用鉴定出了钙三醇酸。有证据表明，钙三醇酸盐源自24-氧化途径，可能是通过中间产物24,25,26,27-四降-1,23-二羟基维生素D3。骨细胞中通向钙三醇酸的24-氧化途径受1,25-二羟基维生素D3刺激。骨细胞和灌注肾脏中的该途径在底物的生理浓度下起作用，并且似乎能够快速清除该激素。