维生素 D 在多发性硬化症中的免疫调节作用和治疗潜力。
Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis.
机构信息
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
出版信息
Br J Pharmacol. 2020 Sep;177(18):4113-4133. doi: 10.1111/bph.15201. Epub 2020 Aug 5.
Abstract
Initially recognised as an important factor for bone health, vitamin D is now known to have a range of effects on the immune system. Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS), a chronic immune-mediated demyelinating disease of the CNS. In this review, we explore the links between vitamin D deficiency, MS risk, and disease activity. We also discuss the known immune effects of vitamin D supplementation and the relevance of these observations to the immunopathology of MS. Finally, we review the existing evidence for vitamin D supplementation as an MS therapy, highlighting several recent clinical studies and trials.
摘要
最初被认为是骨骼健康的重要因素，现在已知维生素 D 对免疫系统有多种影响。维生素 D 缺乏与多发性硬化症（MS）的风险增加有关，MS 是一种中枢神经系统的慢性免疫介导的脱髓鞘疾病。在这篇综述中，我们探讨了维生素 D 缺乏、MS 风险和疾病活动之间的联系。我们还讨论了维生素 D 补充的已知免疫作用以及这些观察结果与 MS 免疫病理学的相关性。最后，我们回顾了维生素 D 补充作为 MS 治疗的现有证据，重点介绍了几项最近的临床研究和试验。
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