Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Laboratory of Molecular Immunology, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Trends Mol Med. 2017 Mar;23(3):216-226. doi: 10.1016/j.molmed.2017.01.006. Epub 2017 Feb 7.
mRNA vaccines have emerged as potent tools to elicit antitumor T cell immunity. They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival. Recent reports have attributed opposing roles for type I IFNs in modulating CD8+ T cell immunity to mRNA vaccines, from profoundly stimulatory to strongly inhibitory. The mechanisms behind this duality are unclear. Disentangling the factors governing the beneficial or detrimental impact of type I IFNs on CD8+ T cell responses is vital to the design of mRNA vaccines of increased potency. In light of recent advancements regarding the complex role of type I IFNs in regulating CD8+ T cell immunity to infectious diseases, we posit that the dual outcome of type I IFNs on CD8+ T cell responses to mRNA vaccination is determined by the timing and intensity of type I IFN induction relative to T cell receptor (TCR) activation.
mRNA 疫苗已成为引发抗肿瘤 T 细胞免疫的有效工具。它们的特点是强烈诱导 I 型干扰素 (IFN)，强烈影响 T 细胞分化和存活的炎症细胞因子。最近的报道归因于 I 型 IFN 在调节 mRNA 疫苗的 CD8+ T 细胞免疫中的相反作用，从强烈刺激到强烈抑制。这种二元性的机制尚不清楚。阐明决定 I 型 IFN 对 CD8+ T 细胞反应有益或有害影响的因素对于设计更有效的 mRNA 疫苗至关重要。鉴于最近关于 I 型 IFN 在调节 CD8+ T 细胞对传染病的免疫中的复杂作用的进展，我们假设 I 型 IFN 对 mRNA 疫苗接种后 CD8+ T 细胞反应的双重影响取决于与 TCR 激活相比 I 型 IFN 诱导的时间和强度。
