钴催化酮与伯醇的α-烷基化反应。
Cobalt-Catalyzed α-Alkylation of Ketones with Primary Alcohols.
机构信息
Department of Sciences, John Jay College and Ph.D. Program in Chemistry, The Graduate Center of the City University of New York , New York, New York 10019, United States.
Department of Chemistry, Hunter College, the City University of New York , New York, New York 10065, United States.
出版信息
Org Lett. 2017 Mar 3;19(5):1080-1083. doi: 10.1021/acs.orglett.7b00106. Epub 2017 Feb 10.
An ionic cobalt-PNP complex is developed for the efficient α-alkylation of ketones with primary alcohols for the first time. A broad range of ketone and alcohol substrates were employed, leading to the isolation of alkylated ketones with yields up to 98%. The method was successfully applied to the greener synthesis of quinoline derivatives while using 2-aminobenzyl alcohol as an alkylating reagent.
首次开发了一种离子型钴-PNP 配合物，用于高效地实现酮与伯醇的α-烷基化反应。该方法适用范围广泛，可用于多种酮和醇底物，以高达 98%的产率得到烷基化酮产物。该方法还成功地应用于以 2-氨基苄醇为烷基化试剂的绿色合成喹啉衍生物。
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