2型糖尿病骨质疏松性改变的评估：一项回顾性研究。
Assessment of osteoporotic alterations in type 2 diabetes: a retrospective study.
作者信息
Munhoz Luciana, Cortes Arthur R G, Arita Emiko S
机构信息
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
出版信息
Dentomaxillofac Radiol. 2017 Aug;46(6):20160414. doi: 10.1259/dmfr.20160414. Epub 2017 Mar 28.
OBJECTIVES
To analyze the influence of Type 2 diabetes on bone mineral density (BMD) and panoramic radiomorphometry in postmenopausal females, comparing with results from non-diabetic postmenopausal females.
METHODS
A total of 228 postmenopausal females (mean age: 59.51 ± 11.08 years) were included in this study. Demographics, T scores and Z scores from peripheral dual X-ray absorptiometry (DXA) and mandibular cortical index (MCI) from panoramic radiographs were assessed. Mean comparison between results for diabetics and non-diabetics was carried out with the Student's t-test. In addition, non-parametric correlations between MCI and DXA results were carried out with Spearman's test, at a level of significance of 5%.
RESULTS
Mean Z score values were significantly higher in diabetics than in non-diabetics (p = 0.001). T and Z score values were also significantly correlated with MCI (r = 0.428, p = 0.001, and r = 0.356, p = 0.022, respectively).
CONCLUSIONS
Within the limitations of this study, the present results suggest that Type 2 diabetes might increase BMD in postmenopausal females.
目的
分析2型糖尿病对绝经后女性骨密度（BMD）和全景放射形态测量的影响，并与非糖尿病绝经后女性的结果进行比较。
方法
本研究共纳入228名绝经后女性（平均年龄：59.51±11.08岁）。评估了人口统计学数据、外周双能X线吸收法（DXA）的T值和Z值以及全景X线片的下颌骨皮质指数（MCI）。使用学生t检验对糖尿病患者和非糖尿病患者的结果进行均值比较。此外，使用Spearman检验对MCI和DXA结果进行非参数相关性分析，显著性水平为5%。
结果
糖尿病患者的平均Z值显著高于非糖尿病患者（p = 0.001）。T值和Z值也与MCI显著相关（分别为r = 0.428，p = 0.001和r = 0.356，p = 0.022）。
结论
在本研究的局限性内，目前的结果表明2型糖尿病可能会增加绝经后女性的骨密度。
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