中性粒细胞与淋巴细胞比值在宫颈癌中的预后意义：一项观察性研究的系统评价和荟萃分析
Prognostic significance of neutrophil-to-lymphocyte ratio in cervical cancer: A systematic review and meta-analysis of observational studies.
作者信息
Huang Qi-Tao, Man Qian-Qian, Hu Jia, Yang Yi-Lin, Zhang Yue-Mei, Wang Wei, Zhong Mei, Yu Yan-Hong
机构信息
Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Southern Medical University, Guangzhou, 510515, China.
出版信息
Oncotarget. 2017 Mar 7;8(10):16755-16764. doi: 10.18632/oncotarget.15157.
BACKGROUND AND AIMS
The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in cervical cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in cervical cancer.
RESULTS
A total of 9 studies, consisting of 2,804 patients, were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (HR: 1.88, 95% CI 1.30-2.73) and shorter progression free survival (HR 1.65, 95% CI 1.18-2.29). Additionally, increased NLR was also significantly correlated with tumor size (OR 2.05, 95% CI 1.14-3.65), advanced FIGO stage (OR 2.12, 95% CI1.28-3.49) and lymph node involvement (OR 2.24, 95% CI 1.65-3.04).
MATERIALS AND METHODS
We conducted a systematic literature search using the electronic databases PubMed, Web of Science, and Embase up to May 2016.Statistical analysis was performed using Stata 10.0.
CONCLUSIONS
Elevated pretreatment NLR could serve as a predicative factor of poor prognosis for cervical cancer patients.
背景与目的
中性粒细胞与淋巴细胞比值（NLR）在宫颈癌中的预后作用存在争议。我们进行了这项荟萃分析，以更准确地评估NLR在宫颈癌中的预后意义。
结果
本荟萃分析共纳入9项研究，涉及2804例患者。我们的汇总结果显示，治疗前NLR水平较高与较差的总生存期（HR：1.88，95%CI 1.30 - 2.73）和较短的无进展生存期（HR 1.65，95%CI 1.18 - 2.29）显著相关。此外，NLR升高还与肿瘤大小（OR 2.05，95%CI 1.14 - 3.65）、国际妇产科联盟（FIGO）分期较晚（OR 2.12，95%CI 1.28 - 3.49）和淋巴结受累（OR 2.24，95%CI 1.65 - 3.04）显著相关。
材料与方法
我们使用电子数据库PubMed、Web of Science和Embase进行了系统的文献检索，检索截至2016年5月。使用Stata 10.0进行统计分析。
结论
治疗前NLR升高可作为宫颈癌患者预后不良的预测因素。
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