中性粒细胞与淋巴细胞比值在卵巢癌中的预后意义：一项观察性研究的系统评价和荟萃分析

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis of Observational Studies.

作者信息

Huang Qi-Tao, Zhou Lin, Zeng Wen-Juan, Ma Qian-Qian, Wang Wei, Zhong Mei, Yu Yan-Hong

机构信息

Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Southern Medical University, Guangzhou, China.

出版信息

Cell Physiol Biochem. 2017;41(6):2411-2418. doi: 10.1159/000475911. Epub 2017 May 3.

DOI:10.1159/000475911

PMID:28467978

Abstract

BACKGROUND AND AIMS

Published data on the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer are controversial. We conducted this meta-analysis to obtain a more accurate assessment of prognostic significance of NLR in ovarian cancer.

MATERIALS AND METHODS

We conducted a systematic literature search using the electronic databases PubMed, Web of Science, and Embase up to May 2016. Hazard ratio (HR) and odd ratio (OR) with 95% confidence interval (95% CI) were calculated. Subgroup analyses were carried out to explore the source of heterogeneity. Statistical analysis was performed using Stata 10.0.

RESULTS

A total of 12 studies, consisting of 3,854 patients, which met our criterion were selected in this meta-analysis. Our pooled results showed that high pre-treatment NLR level was significantly associated with poorer overall survival (OS) (HR: 1.69, 95% CI 1.29-2.22) and shorter progression free survival (PFS) (HR 1.63, 95% CI 1.27-2.09). Additionally, increased NLR was also significantly correlated with advanced FIGO stage (OR 2.32, 95% CI1.79-3.00), higher serum level of CA-125 (OR 3.33, 95% CI 2.43-4.58), more extensive ascites (OR 3.54, 95% CI 2.31-5.42) as well as less chemotheraputic response (OR 0.53, 95% CI 0.40-0.70). The findings from most of subgroup meta-analyses were consistent with those from the overall meta-analyses.

CONCLUSIONS

Elevated pre-treatment NLR could served as a predicative factor of poor prognosis for ovarian cancer patients.

摘要

背景与目的

关于中性粒细胞与淋巴细胞比值（NLR）在卵巢癌预后中的作用，已发表的数据存在争议。我们进行这项荟萃分析，以更准确地评估NLR在卵巢癌中的预后意义。

材料与方法

我们使用电子数据库PubMed、科学网和Embase进行了系统的文献检索，检索截至2016年5月。计算了风险比（HR）和比值比（OR）以及95%置信区间（95%CI）。进行亚组分析以探索异质性来源。使用Stata 10.0进行统计分析。

结果

本荟萃分析共纳入12项研究，包括3854例患者，这些研究符合我们的标准。我们的汇总结果显示，治疗前NLR水平高与较差的总生存期（OS）（HR：1.69，95%CI 1.29 - 2.22）和较短的无进展生存期（PFS）（HR 1.63，95%CI 1.27 - 2.09）显著相关。此外，NLR升高还与国际妇产科联盟（FIGO）晚期（OR 2.32，95%CI 1.79 - 3.00）、较高的血清CA - 125水平（OR 3.33，95%CI 2.43 - 4.58）、更广泛的腹水（OR 3.54，95%CI 2.31 - 5.42）以及较低的化疗反应（OR 0.53，95%CI 0.40 - 0.70）显著相关。大多数亚组荟萃分析的结果与总体荟萃分析的结果一致。