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[采用血卟啉衍生物的光动力激光肿瘤疗法治疗外耳棘细胞癌]

[Photodynamic laser tumor therapy with a hematoporphyrin derivative in spinocellular carcinoma of the external ear].

作者信息

Feyh J, Goetz A, Martin F, Lumper W, Müller W, Brendel W, Kastenbauer E

机构信息

Klinik und Poliklinik für Hals-, Nasen-Ohrenheilkunde, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.

出版信息

Laryngorhinootologie. 1989 Oct;68(10):563-5. doi: 10.1055/s-2007-998401.

Abstract

Haematoporphyrine-derivative (hpd) selectively photosensitises malignant tumours following intravenous application. 48 hours after injection of hpd an integral laser-light application of the tumour and the surrounding normal tissue was performed. We report on the successful administration of this photodynamic therapy in a patient with a spinocellular carcinoma of the auricle. 16 days after therapy the tumour showed a complete response without damage of the also irradiated surrounding normal tissue. Apart from a temporary sensitivity to light no side effects of the therapy were seen.

摘要

血卟啉衍生物(hpd)静脉注射后可选择性地使恶性肿瘤产生光致敏作用。注射hpd 48小时后,对肿瘤及其周围正常组织进行了一次整体激光照射。我们报告了该光动力疗法在一名耳廓棘细胞癌患者中的成功应用。治疗16天后,肿瘤出现完全缓解,同时接受照射的周围正常组织未受损伤。除了对光有短暂的敏感性外,未观察到该疗法的其他副作用。

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