一分钟坐站测试在囊性纤维化中的应用——对心肺反应的深入了解。
The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses.
机构信息
Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zurich, Switzerland.
Paediatric Department, Julius-Maximilians University Würzburg, Wuerzburg, Germany.
出版信息
J Cyst Fibros. 2017 Nov;16(6):744-751. doi: 10.1016/j.jcf.2017.01.012. Epub 2017 Feb 7.
BACKGROUND
We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (Power) as a measure of exercise capacity.
METHODS
Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis.
RESULTS
Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. Power showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload.
CONCLUSIONS
The 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While Power and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical.
背景
本研究旨在描述囊性纤维化（CF）患者 1 分钟坐站（STS）测试过程中的心肺反应，并将峰值运动心肺变量与最大心肺运动测试（CPET）进行比较。我们还旨在评估 STS 功率指数（Power）作为运动能力衡量指标的有效性。
方法
15 名成年 CF 患者进行了肺量测定、CPET 和 1 分钟 STS 测试，并进行了呼吸气体分析。
结果
1 分钟 STS 测试时的峰值心肺变量与 CPET 测量值密切相关（r=0.69-0.98）。在 1 分钟 STS 测试中，峰值运动时的摄氧量、二氧化碳产生量、心率、通气量和潮气量分别降低了 24%、26%、9%、10%和 21%，而呼吸频率则升高了 14%。功率与 CPET 衍生的绝对峰值摄氧量和最大工作量呈强到极强相关。
结论
与最大的循环测力计 CPET 相比，1 分钟 STS 测试引起的心肺反应虽然明显但较低。虽然功率和 STS 重复次数都是功能能力的有效衡量指标，但 STS 重复次数在临床上更实用。
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