Damjanović M, Janković B D
Immunology Research Center, Belgrade, Yugoslavia.
Am J Reprod Immunol. 1989 May;20(1):1-8. doi: 10.1111/j.1600-0897.1989.tb00628.x.
Experimental autoimmune oophoritis (EAOO) induced in female Lewis rats by a single injection of isologous ovary in complete Freund's adjuvant (CFA) and concentrated pertussis vaccine resulted in a multifocal accumulation of mononuclear cells in ovaries and complete loss of fertility after 17-28 days. The time course of appearance of anti-ovary antibodies and their serum titers showed a good correlation with the reduction of litter size. Furthermore, the infertility also could be induced by passive immunization of rats with adsorbed anti-ovary serum. The contraceptive effect of the antibody does not result in permanent sterility. Besides lymphoid cell infiltrations, the most prominent histological alterations in ovaries of experimental rats were characterized by a significant increase in the number of atretic preantral and antral follicles and a decrease in the number of growing follicles of all sizes and corpora lutea. It is presumed that both the direct effect of anti-ovary antibodies and disturbance in ovarian morphology can lead to a reduction of litter size and appearance of infertile cycles in rats with oophoritis.
通过在完全弗氏佐剂（CFA）和浓缩百日咳疫苗中单次注射同种异体卵巢，在雌性Lewis大鼠中诱导实验性自身免疫性卵巢炎（EAOO），可导致卵巢中单核细胞多灶性聚集，并在17 - 28天后完全丧失生育能力。抗卵巢抗体出现的时间进程及其血清滴度与产仔数的减少呈现出良好的相关性。此外，用吸附的抗卵巢血清对大鼠进行被动免疫也可诱导不育。抗体的避孕作用不会导致永久性不育。除了淋巴细胞浸润外，实验大鼠卵巢中最显著的组织学改变特征是闭锁的窦前卵泡和窦卵泡数量显著增加，以及各种大小的生长卵泡和黄体数量减少。据推测，抗卵巢抗体的直接作用和卵巢形态的紊乱均可导致卵巢炎大鼠的产仔数减少和不育周期的出现。
