Imperial School of Anaesthesia, London, UK.
Adult ICU, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
Drugs. 2017 Mar;77(4):353-361. doi: 10.1007/s40265-017-0698-0.
Sepsis continues to escape a precise diagnostic definition. The most recent consensus definition, termed Sepsis-3, highlights the importance of the maladaptive and potentially life-threatening host response to infection. After briefly reviewing the history and epidemiology of sepsis, we go on to describe some of the challenges encountered when classifying such a heterogenous disease state. In the context of these new definitions for sepsis and septic shock, we explore current and potentially novel therapies, and conclude by mentioning some of the controversies of this most recent framework.
脓毒症仍然没有一个明确的诊断定义。最近的共识定义，即 Sepsis-3，强调了宿主对感染的适应性和潜在威胁生命的反应的重要性。在简要回顾脓毒症的历史和流行病学后，我们接着描述了在对这种异质性疾病进行分类时遇到的一些挑战。在这些脓毒症和感染性休克的新定义的背景下，我们探讨了当前和潜在的新疗法，并在最后提到了这个最新框架的一些争议。
