Asgarshirazi Masoumeh, Shariat Mamak, Nayeri Fatemeh, Dalili Hosein, Abdollahi Alireza
Department of Pediatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2017 Jan;55(1):53-58.
We conducted this study to compare fecal calprotectin between exclusively breastfed and formula or mixed fed infants aged one month and six months. Sixty term infants were enrolled from the labor ward of Valiasr Hospital between Oct 2011 and July 2015 and their fecal calprotectin was checked by the ELISA method and Hycult biotech kits. The enrolled infants had a birth weight of 2500-4000 g and no perinatal insults or hospitalization. Stool sampling was done at 1±1 week and at 6n±1 months. The six-month infants had no recent disease, antibiotic use or vaccination. The mean fecal calprotectin was higher in exclusively breastfed infants at first and sixth months than formula and mixed fed infants (368.85±204.49 and 283.21±381.41 µg/g versus 152.59±139.13 and 113.62±92.75 µg/g respectively). (P=0.0001 and 0.018) Fecal calprotectin was higher in infants with GERD than healthy babies in the first and sixth months (P=0.0001 and 0.004). Based on the role of calprotectin in inflammation, its higher levels in exclusively breastfed infants is contrary to breast milk benefits and may be a sign of enhanced mucosal immune maturity in them.
我们开展这项研究，以比较纯母乳喂养的1个月和6个月大婴儿与配方奶喂养或混合喂养婴儿的粪便钙卫蛋白水平。2011年10月至2015年7月期间，从瓦利亚斯尔医院产房招募了60名足月儿，采用酶联免疫吸附测定（ELISA）法和Hycult生物技术试剂盒检测他们的粪便钙卫蛋白。入选婴儿出生体重为2500 - 4000克，无围产期损伤或住院史。在1±1周和6±1个月时进行粪便采样。6个月大的婴儿近期无疾病、未使用抗生素或接种疫苗。纯母乳喂养婴儿在第1个月和第6个月时的平均粪便钙卫蛋白水平高于配方奶喂养和混合喂养婴儿（分别为368.85±204.49和283.21±381.41微克/克，而配方奶喂养和混合喂养婴儿分别为152.59±139.13和113.62±92.75微克/克）。（P = 0.0001和0.018）在第1个月和第6个月时，患有胃食管反流病（GERD）的婴儿粪便钙卫蛋白水平高于健康婴儿（P = 0.0001和0.004）。基于钙卫蛋白在炎症中的作用，纯母乳喂养婴儿中其较高水平与母乳的益处相悖，可能是他们黏膜免疫成熟增强的一个迹象。
