Lavies N G, Meiklejohn B H, May A E, Achola K J, Fell D
Department of Anaesthesia, Leicester Royal Infirmary.
Br J Anaesth. 1989 Oct;63(4):429-34. doi: 10.1093/bja/63.4.429.
The pressor and catecholamine responses to laryngoscopy and intubation were studied in nine patients with pregnancy-induced hypertension (PIH) and in eight normotensive controls. Five of the PIH patients had received oral labetalol as antihypertensive therapy. Mean arterial pressure (MAP) increased significantly from the pre-induction value in all groups 1 min after intubation, and also at 3 min in those with PIH who had not received labetalol. Arterial pressure was significantly greater in both PIH groups than in the control group at all times. However, the percentage increase in MAP on intubation was significantly less in the labetalol treated group than in either the untreated or the control groups. There were no significant differences between the groups in plasma concentrations of either noradrenaline or adrenaline; noradrenaline concentration increased significantly after intubation only in the control group. Labetalol appears to confer some protection against the pressor response to intubation in parturients with PIH.
对9例妊娠高血压综合征（PIH）患者和8例血压正常的对照者，研究了喉镜检查及气管插管时的升压反应和儿茶酚胺反应。5例PIH患者接受了口服拉贝洛尔作为抗高血压治疗。插管后1分钟，所有组的平均动脉压（MAP）均较诱导前值显著升高，未接受拉贝洛尔治疗的PIH患者在3分钟时也是如此。所有时间点，两个PIH组的动脉压均显著高于对照组。然而，拉贝洛尔治疗组插管时MAP的升高百分比显著低于未治疗组或对照组。各组间去甲肾上腺素或肾上腺素的血浆浓度无显著差异；仅对照组插管后去甲肾上腺素浓度显著升高。拉贝洛尔似乎对PIH产妇插管时的升压反应有一定的保护作用。
