Kumar N, Batra Y K, Bala I, Gopalan S
Department of Anaesthesiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Can J Anaesth. 1993 Apr;40(4):329-33. doi: 10.1007/BF03009631.
Thirty women with pregnancy-induced hypertension (PIH) scheduled for Caesarean section under general anaesthesia were studied to evaluate the efficacy of sublingual nifedipine in attenuating the pressor response to laryngoscopy and tracheal intubation. The patients were randomly given either the contents of a nifedipine capsule 10 mg or placebo sublingually 20 min before induction of anaesthesia. Blood pressure and heart rate were recorded at various time intervals. There was a decrease in mean arterial blood pressure (MAP) after pretreatment with nifedipine (P < 0.01). The increase in MAP during laryngoscopy and intubation was higher in the control group compared with nifedipine pretreatment group (P < 0.01). During laryngoscopy and intubation, MAP decreased by 3 mmHg in the nifedipine pretreatment group, while there was an increase of 14 mmHg in the control group. Heart rate increased in both the groups during the laryngoscopy and tracheal intubation (P < 0.01) but the increase was higher in the nifedipine group than in the control group (P < 0.05). Neonatal Apgar scores in both the groups were comparable. These results suggest that sublingual nifedipine is effective in attenuating the hypertensive response to laryngoscopy and intubation but not the tachycardiac response in parturients with PIH.
对30例计划在全身麻醉下行剖宫产术的妊娠高血压综合征（PIH）患者进行研究，以评估舌下含服硝苯地平减轻喉镜检查和气管插管时升压反应的效果。在麻醉诱导前20分钟，将患者随机分为两组，分别舌下给予10 mg硝苯地平胶囊内容物或安慰剂。在不同时间间隔记录血压和心率。硝苯地平预处理后平均动脉血压（MAP）降低（P < 0.01）。与硝苯地平预处理组相比，对照组在喉镜检查和插管期间MAP升高幅度更大（P < 0.01）。在喉镜检查和插管期间，硝苯地平预处理组MAP下降3 mmHg，而对照组升高14 mmHg。两组在喉镜检查和气管插管期间心率均增加（P < 0.01），但硝苯地平组增加幅度高于对照组（P < 0.05）。两组新生儿Apgar评分相当。这些结果表明，舌下含服硝苯地平可有效减轻PIH产妇对喉镜检查和插管的高血压反应，但不能减轻心动过速反应。
