β-arrestins 调控炎症反应：不仅仅是受体的故事。
Regulation of inflammation by β-arrestins: Not just receptor tales.
机构信息
Department of Medicine (Cardiology), Duke University Medical Center, Durham, North, Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North, Carolina, USA.
出版信息
Cell Signal. 2018 Jan;41:41-45. doi: 10.1016/j.cellsig.2017.02.008. Epub 2017 Feb 9.
Abstract
The ubiquitously expressed, multifunctional scaffolding proteins β-arrestin1 and β-arrestin2 each affect inflammatory signaling in a variety of cell lines. In addition to binding the carboxyl-terminal tails of innumerable 7-transmembrane receptors, β-arrestins scaffold untold numbers of other plasma membrane and cytoplasmic proteins. Consequently, the effects of β-arrestins on inflammatory signaling are diverse, and context-specific. This review highlights the roles of β-arrestins in regulating canonical activation of the pro-inflammatory transcription factor NFκB.
摘要
广泛表达的多功能支架蛋白β-arrestin1 和 β-arrestin2 均可影响多种细胞系中的炎症信号转导。β-arrestin 除了与无数 7 跨膜受体的羧基末端尾巴结合之外，还支架无数其他质膜和细胞质蛋白。因此，β-arrestin 对炎症信号转导的影响是多样化的，且具有特定的上下文依赖性。本综述重点介绍了β-arrestin 在调节促炎转录因子 NFκB 的经典激活中的作用。
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