Parkes Shauna L, Furlong Teri M, Black Alanna D, Balleine Bernard W
Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia.
Appetite. 2017 Jun 1;113:1-6. doi: 10.1016/j.appet.2017.02.009. Epub 2017 Feb 8.
The influence of binge-like feeding schedules on subsequent food-related behavior is not well understood. We investigated the effect of repeated cycles of restriction and refeeding on two food-related behaviors; goal-directed responding for a palatable food reward and sensory-specific satiety. Hungry rats were trained to perform two instrumental actions for two distinct food outcomes and were then subjected to repeated cycles of restricted and unrestricted access to their maintenance chow for 30-days or were maintained on food restriction. Goal-directed control was then assessed using specific satiety-induced outcome devaluation. Rats were given 1 h access to one of theoutcomes and were then immediately given a choice between the two actions. Rats maintained on restriction responded more for the valued than the devalued reward but rats with a history of restriction and refeeding failed to show this effect. Importantly, all rats showed sensory-specific satiety when offered a choice between the two foods, indicating that pre-feeding selectively reduced the value of the pre-fed food. By contrast, sensory-specific satiety was not observed in rats with a history of intermittent feeding when the foods were offered sequentially. These results indicate that, similar to calorically dense diets, intermittent feeding patterns can impair the performance of goal-directed actions as well as the ability to reject a pre-fed food when it is offered alone.
暴饮暴食式的进食模式对后续与食物相关行为的影响尚未得到充分理解。我们研究了反复的限制进食和再进食周期对两种与食物相关行为的影响；对美味食物奖励的目标导向反应和感官特异性饱腹感。饥饿的大鼠被训练为两种不同的食物结果执行两种工具性动作，然后经历30天的反复限制和不受限制获取维持饲料的周期，或者持续处于食物限制状态。然后使用特定饱腹感诱导的结果贬值来评估目标导向控制。给大鼠1小时获取其中一种结果的机会，然后立即让它们在两种动作之间进行选择。持续处于限制状态的大鼠对有价值的奖励比对贬值的奖励反应更多，但有过限制和再进食历史的大鼠没有表现出这种效应。重要的是，当在两种食物之间进行选择时，所有大鼠都表现出感官特异性饱腹感，这表明预喂食选择性地降低了预喂食物的价值。相比之下，当食物依次提供时，有间歇性进食历史的大鼠没有观察到感官特异性饱腹感。这些结果表明，与高热量饮食类似，间歇性进食模式会损害目标导向行为的表现以及单独提供预喂食物时拒绝它的能力。
