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1
Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%.0.5%噻吗洛尔单药治疗未控制的开角型青光眼患者中，0.5%噻吗洛尔与2%毛果芸香碱固定比例组合对眼压24小时昼夜曲线的影响。
Br J Ophthalmol. 1989 Oct;73(10):827-31. doi: 10.1136/bjo.73.10.827.
2
Clinical experience with a fixed dose combination therapy of timolol and pilocarpine used twice daily in the management of chronic open angle glaucoma.噻吗洛尔与毛果芸香碱固定剂量复方疗法每日两次用于慢性开角型青光眼治疗的临床经验。
Eye (Lond). 1994;8 ( Pt 4):410-3. doi: 10.1038/eye.1994.97.
3
Intraocular pressure-lowering effects of latanoprost monotherapy versus latanoprost or pilocarpine in combination with timolol: a randomized, observer-masked multicenter study in patients with open-angle glaucoma. Italian Latanoprost Study Group.拉坦前列素单药治疗与拉坦前列素或毛果芸香碱联合噻吗洛尔降低眼压的效果比较：一项针对开角型青光眼患者的随机、观察者盲法多中心研究。意大利拉坦前列素研究组
J Glaucoma. 1999 Feb;8(1):24-30.
4
A double-masked study of timolol and pilocarpine combined.噻吗洛尔与毛果芸香碱联合使用的双盲研究。
Am J Ophthalmol. 1987 Dec 15;104(6):587-90. doi: 10.1016/0002-9394(87)90168-1.
5
Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension.拉坦前列素与毛果芸香碱/马来酸噻吗洛尔固定组合治疗原发性开角型青光眼或高眼压症患者的疗效与安全性。
Acta Ophthalmol. 2008 Dec;86(8):860-5. doi: 10.1111/j.1755-3768.2008.01324.x. Epub 2008 Aug 20.
6
Timolol-pilocarpine fixed-ratio combinations in the treatment of chronic open angle glaucoma. A controlled multicenter study of 48 weeks. Scandinavian Timpilo Study Group.
Arch Ophthalmol. 1992 Dec;110(12):1725-9. doi: 10.1001/archopht.1992.01080240065032.
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Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma.从噻吗洛尔联合毛果芸香碱转换为比马前列素单药治疗对原发性慢性闭角型青光眼眼血流和眼压的影响。
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8
[Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients].原发性开角型青光眼或高眼压症患者中，0.5%噻吗洛尔/2%多佐胺固定复方制剂与0.5%噻吗洛尔/2%毛果芸香碱固定复方制剂的对比研究
Klin Oczna. 2004;106(1-2 Suppl):241-2.
9
Comparison of the intraocular pressure lowering effect of latanoprost and a fixed combination of timolol-pilocarpine eye drops in patients insufficiently controlled with beta adrenergic antagonists. French Latanoprost Study Group, and the Swedish Latanoprost Study Group.拉坦前列素与噻吗洛尔-毛果芸香碱滴眼液固定组合对β-肾上腺素能拮抗剂控制不佳的患者降低眼压效果的比较。法国拉坦前列素研究组和瑞典拉坦前列素研究组。
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Timolol-pilocarpine combined vs timolol and pilocarpine given separately.
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引用本文的文献

1
Use of fixed-dose combination drugs for the treatment of glaucoma.使用固定剂量复方药物治疗青光眼。
Drugs Aging. 2007;24(12):1007-16. doi: 10.2165/00002512-200724120-00004.
2
Pharmacological therapy for glaucoma: a review.青光眼的药物治疗：综述
Drugs. 2000 Mar;59(3):411-34. doi: 10.2165/00003495-200059030-00003.

本文引用的文献

1
The significance of the diurnal tension variations in normal and glaucomatous eyes.正常眼和青光眼眼中昼夜眼压变化的意义。
Arch Ophthalmol. 1960 Oct;64:494-501. doi: 10.1001/archopht.1960.01840010496004.
2
Evaluation of timolol in chronic open-angle glaucoma. Once a day vs twice a day.
Arch Ophthalmol. 1980 Dec;98(12):2178-81. doi: 10.1001/archopht.1980.01020041030004.
3
Frequency of timolol administration.噻吗洛尔的给药频率。
Am J Ophthalmol. 1981 Oct;92(4):526-9. doi: 10.1016/0002-9394(81)90645-0.
4
Compliance with topical pilocarpine treatment.局部毛果芸香碱治疗的依从性。
Am J Ophthalmol. 1986 May 15;101(5):515-23. doi: 10.1016/0002-9394(86)90939-6.
5
A double-masked study of timolol and pilocarpine combined.噻吗洛尔与毛果芸香碱联合使用的双盲研究。
Am J Ophthalmol. 1987 Dec 15;104(6):587-90. doi: 10.1016/0002-9394(87)90168-1.

0.5%噻吗洛尔单药治疗未控制的开角型青光眼患者中，0.5%噻吗洛尔与2%毛果芸香碱固定比例组合对眼压24小时昼夜曲线的影响。

Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%.

作者信息

Maclure G M, Vogel R, Sturm A, Binkowitz B

机构信息

North Riding Infirmary, Middlesbrough, Cleveland.

出版信息

Br J Ophthalmol. 1989 Oct;73(10):827-31. doi: 10.1136/bjo.73.10.827.

DOI:10.1136/bjo.73.10.827
PMID:2818993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1041894/
Abstract

Eight patients with chronic open-angle glaucoma who had an intraocular pressure greater than 24 mm Hg at some time during the day while taking timolol 0.5% twice daily were given the fixed ratio combination of timolol 0.5% with pilocarpine 2% (TP2) twice daily. By comparing full 24-hour diurnal curves on timolol with those on TP2 it was possible to show that all patients except one (at a single timepoint) had an IOP less than 22 mm Hg when changed to TP2. The mean IOPs, the area under the diurnal pressure curve, and the diurnal variation were all significantly lower on TP2 twice daily than on timolol 0.5% twice daily.

摘要

八名慢性开角型青光眼患者，在每日两次使用0.5%噻吗洛尔期间，白天某些时段眼压高于24 mmHg，改为每日两次使用0.5%噻吗洛尔与2%毛果芸香碱的固定比例组合（TP2）。通过比较使用噻吗洛尔时的完整24小时昼夜眼压曲线与使用TP2时的曲线，发现除一名患者（在单个时间点）外，所有患者改用TP2后眼压均低于22 mmHg。每日两次使用TP2时的平均眼压、昼夜压力曲线下面积和昼夜眼压波动均显著低于每日两次使用0.5%噻吗洛尔时。