0.5%噻吗洛尔单药治疗未控制的开角型青光眼患者中，0.5%噻吗洛尔与2%毛果芸香碱固定比例组合对眼压24小时昼夜曲线的影响。
Effect on the 24-hour diurnal curve of intraocular pressure of a fixed ratio combination of timolol 0.5% and pilocarpine 2% in patients with COAG not controlled on timolol 0.5%.
作者信息
Maclure G M, Vogel R, Sturm A, Binkowitz B
机构信息
North Riding Infirmary, Middlesbrough, Cleveland.
出版信息
Br J Ophthalmol. 1989 Oct;73(10):827-31. doi: 10.1136/bjo.73.10.827.
Eight patients with chronic open-angle glaucoma who had an intraocular pressure greater than 24 mm Hg at some time during the day while taking timolol 0.5% twice daily were given the fixed ratio combination of timolol 0.5% with pilocarpine 2% (TP2) twice daily. By comparing full 24-hour diurnal curves on timolol with those on TP2 it was possible to show that all patients except one (at a single timepoint) had an IOP less than 22 mm Hg when changed to TP2. The mean IOPs, the area under the diurnal pressure curve, and the diurnal variation were all significantly lower on TP2 twice daily than on timolol 0.5% twice daily.
八名慢性开角型青光眼患者，在每日两次使用0.5%噻吗洛尔期间，白天某些时段眼压高于24 mmHg，改为每日两次使用0.5%噻吗洛尔与2%毛果芸香碱的固定比例组合（TP2）。通过比较使用噻吗洛尔时的完整24小时昼夜眼压曲线与使用TP2时的曲线，发现除一名患者（在单个时间点）外，所有患者改用TP2后眼压均低于22 mmHg。每日两次使用TP2时的平均眼压、昼夜压力曲线下面积和昼夜眼压波动均显著低于每日两次使用0.5%噻吗洛尔时。
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